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Ceruloplasmin antibody

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Sheep anti Human Ceruloplasmin

Product Type
Polyclonal Antibody
Isotype
Polyclonal IgG
Specificity
Ceruloplasmin

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Product Code Applications Pack Size List Price Your Price Qty
1940-0004
Datasheet Datasheet Datasheet
SDS Safety Datasheet SDS
C E 1 ml loader
List Price Your Price
loader

Sheep anti Human ceruloplasmin antibody detects ceruloplasmin, a ~132kDa metalloprotein that is secreted into the plasma by liver hepatocytes and activated monocytes/macrophages. Ceruloplasmin functions in copper transport, iron homeostasis, antioxidant defence, angiogenesis and coagulation.

Deficiency in ceruloplasmin is termed aceruloplasminemia, an autosomal recessive disorder which leads to iron accumulation and tissue damage, in particular in the brain and visceral organs. Clinical features include retinal degeneration, diabetes mellitus and neurological disturbances.

Elevated plasma ceruloplasmin has been shown to pose an increased risk in atherosclerosis and myocardial infarction.

Target Species
Human
Product Form
Purified IgG - liquid
Preparation
Purified IgG prepared by affinity chromatography
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.09% Sodium Azide (NaN3)
Immunogen
Highly pure human ceruloplasmin.
Approx. Protein Concentrations
IgG concentration 5.0 mg/ml
Regulatory
For research purposes only
Guarantee
12 months from date of despatch

This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.

Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
ELISA
Immunohistology - Frozen
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using the appropriate negative/positive controls.

ELISA
This antibody has been used at dilutions as high as 1/400K in a simple ELISA with 0.1 µg of antigen coated per well.

Description Product Code Applications Pack Size List Price Your Price Quantity
Rabbit anti Sheep IgG (H/L):Biotin 5184-2304 C E F WB 1.5 ml loader
List Price Your Price
loader
Description Rabbit anti Sheep IgG (H/L):Biotin

References for Ceruloplasmin antibody

  1. Balmaña, M. et al. (2015) Identification of potential pancreatic cancer serum markers: Increased sialyl-Lewis X on ceruloplasmin.
    Clin Chim Acta. 442: 56-62.

Further Reading

  1. Mazumder, B. et al. (2005) Regulation of macrophage ceruloplasmin gene expression: one paradigm of 3'-UTR-mediated translational control.
    Mol Cells. 20 (2): 167-72.

RRID
AB_2085556
UniProt
P00450
Entrez Gene
CP
GO Terms
GO:0051087 chaperone binding
GO:0004322 ferroxidase activity
GO:0005615 extracellular space
GO:0055114 oxidation-reduction process
GO:0006825 copper ion transport
GO:0006879 cellular iron ion homeostasis
GO:0055085 transmembrane transport

1940-0004

1610

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