Sheep anti Human Ceruloplasmin
- Product Type
- Polyclonal Antibody
- Polyclonal IgG
|Sheep anti Human ceruloplasmin antibody detects ceruloplasmin, a ~132kDa metalloprotein that is secreted into the plasma by liver hepatocytes and activated monocytes/macrophages. Ceruloplasmin functions in copper transport, iron homeostasis, antioxidant defence, angiogenesis and coagulation.
Deficiency in ceruloplasmin is termed aceruloplasminemia, an autosomal recessive disorder which leads to iron accumulation and tissue damage, in particular in the brain and visceral organs. Clinical features include retinal degeneration, diabetes mellitus and neurological disturbances.
Elevated plasma ceruloplasmin has been shown to pose an increased risk in atherosclerosis and myocardial infarction.
- Target Species
- Product Form
- Purified IgG - liquid
- Purified IgG prepared by affinity chromatography
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide (NaN3)
- Highly pure human ceruloplasmin.
- Approx. Protein Concentrations
- IgG concentration 5.0 mg/ml
- For research purposes only
- 12 months from date of despatch
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
|Application Name||Verified||Min Dilution||Max Dilution|
|Immunohistology - Frozen|
- This antibody has been used at dilutions as high as 1/400K in a simple ELISA with 0.1 µg of antigen coated per well.
References for Ceruloplasmin antibody
Balmaña, M. et al. (2015) Identification of potential pancreatic cancer serum markers: Increased sialyl-Lewis X on ceruloplasmin.
Clin Chim Acta. 442: 56-62.
Mazumder, B. et al. (2005) Regulation of macrophage ceruloplasmin gene expression: one paradigm of 3'-UTR-mediated translational control.
Mol Cells. 20 (2): 167-72.
Always be the first to know.
When we launch new products and resources to help you achieve more in the lab.Yes, sign me up