Ceruloplasmin antibody
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Sheep anti Human Ceruloplasmin
- Product Type
- Polyclonal Antibody
- Isotype
- Polyclonal IgG
- Specificity
- Ceruloplasmin
Antibody Quality and Performance Guarantee
| Sheep anti Human ceruloplasmin antibody detects ceruloplasmin, a ~132kDa metalloprotein that is secreted into the plasma by liver hepatocytes and activated monocytes/macrophages. Ceruloplasmin functions in copper transport, iron homeostasis, antioxidant defence, angiogenesis and coagulation. Deficiency in ceruloplasmin is termed aceruloplasminemia, an autosomal recessive disorder which leads to iron accumulation and tissue damage, in particular in the brain and visceral organs. Clinical features include retinal degeneration, diabetes mellitus and neurological disturbances. Elevated plasma ceruloplasmin has been shown to pose an increased risk in atherosclerosis and myocardial infarction. |
- Target Species
- Human
- Product Form
- Purified IgG - liquid
- Preparation
- Purified IgG prepared by affinity chromatography
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide (NaN3)
- Immunogen
- Highly pure human ceruloplasmin.
- Approx. Protein Concentrations
- IgG concentration 5.0 mg/ml
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| ELISA |  |
||
| Immunohistology - Frozen | |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using the appropriate negative/positive controls.
- ELISA
- This antibody has been used at dilutions as high as 1/400K in a simple ELISA with 0.1 µg of antigen coated per well.
| Description | Product Code | Applications | Pack Size | List Price | Your Price | Quantity | |
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| Rabbit anti Sheep IgG (H/L):Biotin | 5184-2304 | C E F WB | 1.5 ml |
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| Description | Rabbit anti Sheep IgG (H/L):Biotin | ||||||
| Donkey anti Sheep/Goat IgG:DyLight®488 | STAR88D488GA | F IF | 0.1 mg |
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| Description | Donkey anti Sheep/Goat IgG:DyLight®488 | ||||||
| Donkey anti Sheep/Goat IgG:HRP | STAR88P | C E P WB | 1 ml |
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| Description | Donkey anti Sheep/Goat IgG:HRP | ||||||
References for Ceruloplasmin antibody
-
Balmaña, M. et al. (2015) Identification of potential pancreatic cancer serum markers: Increased sialyl-Lewis X on ceruloplasmin.
Clin Chim Acta. 442: 56-62.
Further Reading
-
Mazumder, B. et al. (2005) Regulation of macrophage ceruloplasmin gene expression: one paradigm of 3'-UTR-mediated translational control.
Mol Cells. 20 (2): 167-72.
- RRID
- AB_2085556
- UniProt
- P00450
- Entrez Gene
- CP
- GO Terms
- GO:0051087 chaperone binding
- GO:0004322 ferroxidase activity
- GO:0005615 extracellular space
- GO:0055114 oxidation-reduction process
- GO:0006825 copper ion transport
- GO:0006879 cellular iron ion homeostasis
- GO:0055085 transmembrane transport
1940-0004
1610
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"
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