C3c antibody

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E ResetSheep anti Human C3c
- Product Type
- Polyclonal Antibody
- Isotype
- Polyclonal IgG
- Specificity
- C3c
Sheep anti Human C3c antibody detects human complement 3c, a polypeptide fragment which is present in C3. C3 plays a central role in the activation of the complement system. Processing of C3 by C3 convertase is the central reaction in both classical and alternative complement pathways, resulting in C3a and C3b. C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates, and help to initiate the complement cascade, potentially resulting in cellular apoptosis. C3a anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes. C3b is rapidly split in two positions by factor I and a cofactor to form iC3b (inactivated C3b) and C3f which is released. Then iC3b is slowly cleaved (possibly by factor I) to form C3c and C3dg. Defects in C3 can result in susceptibility to pyogenic infection. This antbody shows minimal reactivity with related serum proteins. |
- Target Species
- Human
- Product Form
- Purified IgG - liquid
- Preparation
- Purified IgG prepared by affinity chromatography on Protein G
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide (NaN3)
- Immunogen
- Native human C3c purified from serum.
- Approx. Protein Concentrations
- IgG concentration 5.0 mg/ml
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
Application Name | Verified | Min Dilution | Max Dilution |
---|---|---|---|
ELISA | ![]() |
1/400 | |
Immunohistology - Frozen | ![]() |
1/50 |
Description | Product Code | Applications | Pack Size | List Price | Your Price | Quantity | |
---|---|---|---|---|---|---|---|
Rabbit anti Sheep IgG (H/L):Biotin | 5184-2304 | C E F WB | 1.5 ml |
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Description | Rabbit anti Sheep IgG (H/L):Biotin | ||||||
Donkey anti Sheep/Goat IgG:DyLight®488 | STAR88D488GA | F IF | 0.1 mg |
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Description | Donkey anti Sheep/Goat IgG:DyLight®488 | ||||||
Donkey anti Sheep/Goat IgG:HRP | STAR88P | C E P WB | 1 ml |
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Description | Donkey anti Sheep/Goat IgG:HRP |
References for C3c antibody
-
Janssen, B.J. et al. (2005) Structures of complement component C3 provide insights into the function and evolution of immunity.
Nature. 437 (7058): 505-11. -
Lewis, L.A. et al. (2019) Effect of a C1s Inhibitor on the Efficacy of Anti-Capsular Antibodies against Neisseria meningitidis and Streptococcus pneumoniae.
Immunohorizons. 3 (11): 519-30.
- Synonyms
- Complement Component 3c
- RRID
- AB_620389
- UniProt
- P01024
- Entrez Gene
- C3
- GO Terms
- GO:0005102 receptor binding
- GO:0004866 endopeptidase inhibitor activity
- GO:0005615 extracellular space
- GO:0006954 inflammatory response
- GO:0006957 complement activation, alternative pathway
- GO:0006958 complement activation, classical pathway
- GO:0007186 G-protein coupled receptor protein signaling pathway
- GO:0010575 positive regulation vascular endothelial growth factor production
2222-6604


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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"
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