Sheep anti Human lactalbumin antibody detects human alpha-lactalbumin, a small Ca2+ binding protein, the predominant protein found in human milk. Alpha-lactalbumin forms the regulatory subunit of the lactose synthase complex, with beta 1,4-galactosyltransferase forming the catalytic component. Lactose synthase catalyzes and regulates the biosynthesis of lactose in the lactating mammary gland.
A folding variant of alpha-lactalbumin called HAMLET (human alpha-lactalbumin made lethal to tumor cells), has been shown to selectively kill tumor cells and control tumor progression in vivo.
- Target Species
- Species Cross-Reactivity
|Target Species||Cross Reactivity|
- N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Serum - liquid
- Preservative Stabilisers
- Lactalbumin from human milk.
- This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
- 12 months from date of despatch
- Entrez Gene
- GO Terms
calcium ion binding
defense response to bacterium
lactose synthase activity
lactose biosynthetic process
induction of apoptosis
- For research purposes only
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Applications of alpha-Lactalbumin antibody
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using the appropriate negative/positive controls.
Copyright © 2021 Bio-Rad Antibodies (formerly AbD Serotec)
Secondary Antibodies Available
Product Specific References
References for alpha-Lactalbumin antibody
Gustafsson, L. et al. (2005) HAMLET kills tumor cells by apoptosis: structure, cellular mechanisms, and therapy.
J Nutr. 135 (5): 1299-303.
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