Cyclic GMP antibody
Sheep anti cyclic GMP antibody (OBT5055) used for the detection of cyclic GMP in myocardial tissues using immunohistochemistry.
Image caption:
Effect of diabetes mellitus (DM) and cinaciguat treatment on plasma and myocardial cyclic guanosine monophosphate (cGMP) content. a Result of plasma cGMP enzyme immunoassay. b Quantification of cGMP (P value of diabetes × treatment interaction in the two-factorial ANOVA, Pinteraction = 0.025) immunohistochemistry. c Representative images of cGMP immunohistochemistry. Magnification: ×400, Scale bar 40 μm. Groups: vehicle-treated control (Co), cinaciguat-treated control (CoCin), vehicle-treated diabetic (DiabCo) and cinaciguat-treated diabetic (DiabCin). Bar graphs represent mean ± SEM of 9–11 experiments per group. *P < 0.05 vs. Co, †P < 0.05 vs. DiabCo (Tukey HSD test)
From: Mátyás C,
Cardiovasc Diabetol. 2015 Oct 31;14(1):145.
This image is from an open access article distributed under terms of a Creative Commons Attribution License.
Sheep anti Cyclic GMP
- Product Type
- Polyclonal Antibody
- Isotype
- Polyclonal IgG
- Specificity
- Cyclic GMP
Antibody Quality and Performance Guarantee
| Sheep anti cyclic GMP antibody recognizes cyclic guanosine monophosphate (cGMP) a secong messenger molecule similar to cAMP. cGMP is synthesized from GTP under the influence of soluble guanylate synthase. cGMP then activates protein kinases to mediate cellular processes including vasodilation or transcription factor activation. |
- Target Species
- Chemical
- Product Form
- Serum - liquid
- Preservative Stabilisers
- 0.09% Sodium Azide (NaN3)
- Immunogen
- Succinylated cGMP conjugated to BSA.
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
Store at +4°C. DO NOT FREEZE.
This product should be stored undiluted. Should this product contain a precipitate we recommend microcentrifugation before use.
This product should be stored undiluted. Should this product contain a precipitate we recommend microcentrifugation before use.
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| ELISA |  |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
| Description | Product Code | Applications | Pack Size | List Price | Your Price | Quantity | |
|---|---|---|---|---|---|---|---|
| Rabbit anti Sheep IgG (H/L):Biotin | 5184-2304 | C E F WB | 1.5 ml |
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| Description | Rabbit anti Sheep IgG (H/L):Biotin | ||||||
References for Cyclic GMP antibody
-
Mátyás C et al. (2015) The soluble guanylate cyclase activator cinaciguat prevents cardiac dysfunction in a rat model of type-1 diabetes mellitus.
Cardiovasc Diabetol. 14 (1): 145.
- Synonyms
- cGMP
- RRID
- AB_619661
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"
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