anti PGP 9.5 antibody

PGP 9.5 Antibodies

For Alzheimer's and Parkinson's disease research

Recent blog

The emerging importance of ubiquitination regulators in cancer therapy

PGP 9.5 (Protein gene product 9.5) antibody products recognize the ubiquitin hydrolase, PGP 9.5, also known as ubiquitin C-terminal hydrolase 1 (UCHL1). It is involved in the regulation of the ubiquitin pathway and is widely expressed in neuronal tissues, making up 1-2% of soluble brain proteins. 

These antibodies have been found to stain neuronal cell bodies and axons in the CNS and periphery, small nerve fibres in peripheral tissues, neuroendocrine cells in the pituitary, thyroid, pancreas and related tumors. PGP 9.5 is also found in human oocytes and spermatogonia.

PGP 9.5 is a key biomarker for Alzheimer's (Mori et al. 1987) and Parkinson’s disease (Leroy et al. 1988) and has been linked with tumor invasion and progression (Yamazaki et al. 2002).

Did you know?

  1. Our PGP9.5 antibody portfolio comprises 1 goat polyclonal and 3 mouse monoclonal antibodies,
    hat have been tested in IHC-paraffin, ELISA, IF and WB.
  2. Our mouse monoclonals give you high batch to batch consistency and experimental
    reproducibility.
  3. For those of you performing WB analysis, we also offer a
    PrecisonAb™ WB validated antibody (VMA00004K).
  4. The mouse monoclonal antibody (clone 31A3) cross-reacts with human, rat, and rabbit PGP9.5.
  5. This monoclonal is cited in 14 papers, and tested in ELISA, IHC-paraffin and WB.

PGP 9.5 antibody images

Western blot of rat brain probed with Mouse anti Human Protein Gene Product 9.5

Fig 1. Western blot of rat brain probed with Mouse anti Human Protein Gene Product 9.5 (7863-2004), with an approx molecular weight of 27kDa.

2-month-old beagle testes

Fig 2.PGP9.5-positive spermatogonia (arrows) are shown in the top image (3-month-old beagle testes) and the bottom image (2-month-old beagle testes) DOI: 10.1371/journal.pone.0109963.

Histological analysis and spermatogonia detection in 12-month-old beagle testes

Fig 3.Histological analysis and spermatogonia detection in 12-month-old beagle testes. Black arrows indicate PGP 9.5-positve spermatogonia DOI: 10.1371/journal.pone.0109963.


Note: If you are looking for our polyclonal rabbit anti-human protein gene product 9.5 antibody (7863-0504), it is no longer available but here are some suitable alternatives as per below such as our monoclonal mouse anti-human antibody (7863-1004), which was derived using the same immunogen.

Anti-PGP 9.5 antibodies

    DescriptionSpecificityTargetFormatHostIsotypeClone Applications Citations Product Type Code

    Related topics

    References

    Mori H et al. (1987). Ubiquitin is a component of paired helical filaments in Alzheimer’s disease. Science 235, 1641-1644.

    Leroy E et al. (1998). The ubiquitin pathway in Parkinson’s disease. Nature 395, 451-452.

    Yamazaki T et al. (2002). PGP9.5 as a marker for invasive colorectal cancer. Clin Cancer Res 8, 192-195.