For Alzheimer's and Parkinson's disease research
The emerging importance of ubiquitination regulators in cancer therapy
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PGP 9.5 (Protein gene product 9.5) antibody products recognize the ubiquitin hydrolase, PGP 9.5, also known as ubiquitin C-terminal hydrolase 1 (UCHL1). It is involved in the regulation of the ubiquitin pathway and is widely expressed in neuronal tissues, making up 1-2% of soluble brain proteins.
These antibodies have been found to stain neuronal cell bodies and axons in the CNS and periphery, small nerve fibres in peripheral tissues, neuroendocrine cells in the pituitary, thyroid, pancreas and related tumors. PGP 9.5 is also found in human oocytes and spermatogonia.
PGP 9.5 is a key biomarker for Alzheimer's (Mori et al. 1987) and Parkinson’s disease (Leroy et al. 1988) and has been linked with tumor invasion and progression (Yamazaki et al. 2002).
Fig 1. Western blot of rat brain probed with Mouse anti Human Protein Gene Product 9.5 (7863-2004), with an approx molecular weight of 27kDa.
Fig 2.PGP9.5-positive spermatogonia (arrows) are shown in the top image (3-month-old beagle testes) and the bottom image (2-month-old beagle testes) DOI: 10.1371/journal.pone.0109963.
Fig 3.Histological analysis and spermatogonia detection in 12-month-old beagle testes. Black arrows indicate PGP 9.5-positve spermatogonia DOI: 10.1371/journal.pone.0109963.
Note: If you are looking for our polyclonal rabbit anti-human protein gene product 9.5 antibody (7863-0504), it is no longer available but here are some suitable alternatives as per below such as our monoclonal mouse anti-human antibody (7863-1004), which was derived using the same immunogen.
Mori H et al. (1987). Ubiquitin is a component of paired helical filaments in Alzheimer’s disease. Science 235, 1641-1644.
Leroy E et al. (1998). The ubiquitin pathway in Parkinson’s disease. Nature 395, 451-452.
Yamazaki T et al. (2002). PGP9.5 as a marker for invasive colorectal cancer. Clin Cancer Res 8, 192-195.
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