TCR Alpha/Beta antibody | R73

This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.

Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended. This product is photosensitive and should be protected from light.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.

Application Name	Verified	Min Dilution	Max Dilution
Flow Cytometry		Neat	1/5

Flow Cytometry

Use 10ul of the suggested working dilution to label 10⁶ lymphocytes in 100ul.

Description	Product Code	Applications	Pack Size	List Price	Your Price	Quantity
Mouse IgG1 Negative Control:FITC	MCA1209F	F	0.1 mg		Log in	- +	>Add to Cart Get Quote Get Quote Add to Quote
List Price	Your Price
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Description	Mouse IgG1 Negative Control:FITC

Source Reference

1. Hünig, T. et al. (1989) A monoclonal antibody to a constant determinant of the rat T cell antigen receptor that induces T cell activation. Differential reactivity with subsets of immature and mature T lymphocytes.
   J Exp Med. 169 (1): 73-86.

References for TCR Alpha/Beta antibody

1. Tomida, S. et al. (1994) Intercellular adhesion molecule-1 and leukocyte function-associated antigen-1 are involved in protection mediated by CD3+TCR alpha beta- T cells at the early stage after infection with Listeria monocytogenes in rats.
   Int Immunol. 6 (7): 955-61.
2. Colić, M. et al. (1996) Mechanisms involved in the binding of thymocytes to rat thymic dendritic cells.
   Dev Immunol. 5 (1): 37-51.
3. Kanellis, J. et al. (2010) JNK signalling in human and experimental renal ischaemia/reperfusion injury.
   Nephrol Dial Transplant. 25: 2898-908.
4. Nave, H. et al. (2008) Resistance of Janus kinase-2 dependent leptin signaling in natural killer (NK) cells: a novel mechanism of NK cell dysfunction in diet-induced obesity.
   Endocrinology. 149: 3370-8.
5. Tsuchida, M. et al. (1994) Identification of CD4- CD8- alpha beta T cells in the subarachnoid space of rats with experimental autoimmune encephalomyelitis. A possible route by which effector cells invade the lesions.
   Immunology. 81 (3): 420-7.
6. Matsumoto, Y. et al. (1994) Successful prevention and treatment of autoimmune encephalomyelitis by short-term administration of anti-T-cell receptor alpha beta antibody.
   Immunology. 81 (1): 1-7.
7. Pilipović, I. et al. (2010) Glucocorticoids, master modulators of the thymic catecholaminergic system?
   Braz J Med Biol Res. 43 (3): 279-84.
8. Milicevic, N.M. et al. (2005) T cells are required for the peripheral phase of B-cell maturation.
   Immunology. 116: 308-17.
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9. Kenny, E. et al. (2000) Phenotypic analysis of peripheral CD4+ CD8+ T cells in the rat.
   Immunology. 101: 178-84.
10. Petrovic-Dergovic, D.M. et al. (2004) Somatostatin-14 alters the thymus size and relation among the thymocyte subpopulations in peripubertal rats.
    Neuropeptides. 38: 25-34.
11. Trinh, L. et al. (2008) The corneal endothelium in an endotoxin-induced uveitis model: correlation between in vivo confocal microscopy and immunohistochemistry.
    Mol Vis. 14: 1149-56.
12. Khalife, S. et al. (2016) Relationship Between Pneumocystis carinii Burden and the Degree of Host Immunosuppression in an Airborne Transmission Experimental Model.
    J Eukaryot Microbiol. 63 (3): 309-17.
13. Bat, E. et al. (2013) Physical properties and erosion behavior of poly(trimethylene carbonate-co-ε-caprolactone) networks.
    Macromol Biosci. 13 (5): 573-83.
14. Jörns, A. et al. (2015) TNF-α Antibody Therapy in Combination With the T-Cell-Specific Antibody Anti-TCR Reverses the Diabetic Metabolic State in the LEW.1AR1-iddm Rat.
    Diabetes. 64 (8): 2880-91.
15. Ahn, M. et al. (2015) Immunohistochemical study of Krüppel-like factor 4 in the spinal cords of rats with experimental autoimmune encephalomyelitis.
    Acta Histochem. 117 (6): 521-7.
16. Jörns A et al. (2014) Anti-TCR therapy combined with fingolimod for reversal of diabetic hyperglycemia by β cell regeneration in the LEW.1AR1-iddm rat model of type 1 diabetes.
    J Mol Med (Berl). 92 (7): 743-55.
17. Amos, L.A. et al. (2018) ASK1 inhibitor treatment suppresses p38/JNK signalling with reduced kidney inflammation and fibrosis in rat crescentic glomerulonephritis.
    J Cell Mol Med. 22 (9): 4522-33.
18. Koppe, C. et al. (2021) Local Inflammatory Response after Intramuscularly Implantation of Anti-Adhesive Plasma-Fluorocarbon-Polymer Coated Ti6AI4V Discs in Rats.
    Polymers (Basel). 13 (16): 2684.
19. Schmiedl, A. et al. (2021) Lung development and immune status under chronic LPS exposure in rat pups with and without CD26/DPP4 deficiency.
    Cell Tissue Res. Oct 04 [Epub ahead of print].
20. Köhler, R. et al. (2022) Association of systemic antibody response against polyethylene terephthalate with inflammatory serum cytokine profile following implantation of differently coated vascular prostheses in a rat animal model.
    J Biomed Mater Res A. 110 (1): 52-63.
21. Martin, A. et al. (2018) Tumor-derived granzyme B-expressing neutrophils acquire antitumor potential after lipid A treatment.
    Oncotarget. 9 (47): 28364-78.
22. Onaru, K. et al. (2020) Immunotoxicity evaluation by subchronic oral administration of clothianidin in Sprague-Dawley rats.
    J Vet Med Sci. 82 (3): 360-72.

Flow Cytometry

Immunofluorescence

RRID

AB_322439

MCA453F

155275 164959

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