IgA antibody | MARA-1

This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.

Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.

Application Name	Verified	Min Dilution	Max Dilution
ELISA			500ng/ml

References for IgA antibody

1. Goodrich, M.E. and McGee, D.W. (1998) Regulation of mucosal B cell immunoglobulin secretion by intestinal epithelial cell-derived cytokines.
   Cytokine. 10: 948-55.
2. Kushnir, N. et al. (1998) Dendritic cells and resting B cells form clusters in vitro and in vivo: T cell independence, partial LFA-1 dependence, and regulation by cross-linking surface molecules.
   J Immunol. 160: 1774-81.
3. Herías, M.V. et al. (1999) Immunomodulatory effects of Lactobacillus plantarum colonizing the intestine of gnotobiotic rats
   Clin Exp Immunol. 116: 283-90.
4. Bjersing, J.L. et al. (2002) Loss of ileal IgA+ plasma cells and of CD4+ lymphocytes in ileal Peyer's patches of vitamin A deficient rats.
   Clin Exp Immunol. 130: 404-8.
5. Pérez-Cano FJ (2005) Neonatal immunoglobulin secretion and lymphocyte phenotype in rat small intestine lamina propria.
   Pediatr Res. 58: 164-9.
6. Budeč, M. et al. (2007) Possible mechanism of acute effect of ethanol on intestinal IgA expression in rat.
   Int Immunopharmacol. 7: 858-63.
7. Nayak, B.N. et al. (2009) Energy-restricted diets result in higher numbers of CD4+, CD8+, immunoglobulins (A, M, and G), and CD45RA cells in spleen and CD4+, immunoglobulin A, and CD45RA cells in colonic lamina propria of rats.
   Nutr Res. 2009 Jul;29(7):487-93.
8. Budeč, M. et al. (2009) Blockade of nitric oxide synthesis modulates rat immunoglobulin A.
   Neuroimmunomodulation. 16: 155-61.
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9. Hahn, A. et al. (2010) Mesenteric lymph nodes are not required for an intestinal immunoglobulin A response to oral cholera toxin.
   Immunology. 129: 427-36.
10. Ito, H. et al. (2011) Degree of polymerization of inulin-type fructans differentially affects number of lactic acid bacteria, intestinal immune functions, and immunoglobulin A secretion in the rat cecum.
    J Agric Food Chem. 59: 5771-8.
11. Komura, M. et al. (2014) A short-term ingestion of fructo-oligosaccharides increases immunoglobulin A and mucin concentrations in the rat cecum, but the effects are attenuated with the prolonged ingestion.
    Biosci Biotechnol Biochem. 78: 1592-602.
12. Tulinská, J. et al. (2018) Humoral and cellular immune response in Wistar Han RCC rats fed two genetically modified maize MON810 varieties for 90 days (EU 7th Framework Programme project GRACE).
    Arch Toxicol. 92 (7): 2385-99.
13. Hino, S. et al. (2020) Mucin-Derived O-Glycans Act as Endogenous Fiber and Sustain Mucosal Immune Homeostasis via Short-Chain Fatty Acid Production in Rat Cecum.
    J Nutr. 150 (10): 2656-65.

Immunofluorescence

Immunohistology - Frozen

RRID

AB_322197

MCA191B

270514

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