YES1 antibody | E04/5H12

Mouse anti Human YES1

Product Type
PrecisionAb Monoclonal
Clone
E04/5H12
Isotype
IgG1
Format
Purified
Specificity
YES1

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Mouse anti Human YES1 antibody recognizes tyrosine-protein kinase YES, also knowns as p61-Yes or proto-oncogene c-Yes.

YES1 is a member of the SRC family, which also includes SRC, FYN, LYN, and LCK. Members of the SRC family play important roles in a number of cellular processes, including cell growth, adhesion, survival, and differentiation. YES1 has a significant impact on tumor progression in a number of different types of cancer, including cancers of the oesophagus, lung, bladder, head and neck, suggesting that YES1 could be useful as a therapeutic drug target (Takeda et al. 2020).
PrecisionAb Antibodies

Target Species
Human
Western Blotting
Mouse anti Human YES1 antibody detects a band of 58 kDa in K562 cell lysates
Species Cross-Reactivity
Target SpeciesCross Reactivity
Mouse
Rat
N.B. Antibody reactivity and working conditions may vary between species.
Product Form
Purified IgG - liquid
Preparation
Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.09% Sodium Azide (NaN3)
Immunogen
E. coli-derived recombinant protein, aa 1-543 of human YES1
Approx. Protein Concentrations
IgG concentration 1.0 mg/ml
Regulatory
For research purposes only
Guarantee
12 months from date of despatch
Acknowledgements
PrecisionAb is a trademark of Bio-Rad Laboratories

This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.

Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Immunoprecipitation 2.5 µg
Western Blotting 1/1000

The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type

UniProt
P07947
Entrez Gene
YES1
GO Terms
GO:0005886 plasma membrane
GO:0005515 protein binding
GO:0007596 blood coagulation
GO:0005829 cytosol
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0005524 ATP binding
GO:0031295 T cell costimulation
GO:0043114 regulation of vascular permeability
GO:0050900 leukocyte migration
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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