SEC61B antibody | rAB01-4H3

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Anti SEC61B Antibody, clone rAB01-4H3 (PrecisionAb Monoclonal Antibody) thumbnail image 1

Anti SEC61B Antibody, clone rAB01-4H3 (PrecisionAb Monoclonal Antibody) gallery image 1 — Western blot analysis of whole cell lysates probed with SEC61B antibody (1/2,000, **VMA00905**) followed by detection with HRP conjugated Goat anti Mouse IgG (1/10,000, STAR207P) and visualized on the ChemiDoc MP. Arrow points to SEC61B (molecular weight 12 kDa).

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Mouse anti SEC61B

Product Type: PrecisionAb Monoclonal
Clone: rAB01-4H3
Isotype: IgG2a
Format: Purified
Specificity: SEC61B

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VMA00905 Datasheet Datasheet SDS SDS	WB	100 µl		Log in	Get Quote
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Mouse anti SEC61B antibody recognizes protein transport protein Sec61 subunit beta.

SEC61B is a component of the Sec61 translocon (Chiusa et al. 2019), a complex in the endoplasmic reticulum (ER) that mediates membrane insertion of membrane proteins of organelles associated with endocytosis and exocytosis (Lang et al. 2017). The gene encoding SEC61B is associated with polycystic liver diseases, a group of inherited disorders characterized by multiple hepatic cysts (Cornec-Le Gall et al. 2018; Lee-Law et al. 2019).

Target Species: Human
Western Blotting: Mouse anti SEC61B antibody detects a band of approximately 12 kDa in HepG2 cell lysates
Species Cross-Reactivity: Target Species Cross Reactivity

Mouse

Rat; N.B. Antibody reactivity and working conditions may vary between species.
Product Form: Purified IgG - liquid
Preparation: Recombinant IgG prepared by affinity chromatography on Protein A from cell culture supernatant
Buffer Solution: Phosphate buffered saline
Preservative Stabilisers: 0.09% Sodium Azide (NaN₃)
Immunogen: E. coli--derived recombinant protein of amino acids 2-70 of human SEC61B
Approx. Protein Concentrations: IgG concentration 1.0 mg/ml
Regulatory: For research purposes only
Guarantee: As supplied, 12 months from date of despatch
Acknowledgements: PrecisionAb is a trademark of Bio-Rad Laboratories

Target Species	Cross Reactivity
Mouse
Rat

Store undiluted at -20^oC, avoiding repeated freeze thaw cycles

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.

Application Name	Verified	Min Dilution	Max Dilution
Western Blotting		1/2000

Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.

UniProt: P60468
Entrez Gene: SEC61B
GO Terms: GO:0000060 protein import into nucleus, translocation; GO:0016021 integral to membrane; GO:0030433 ER-associated protein catabolic process; GO:0030970 retrograde protein transport, ER to cytosol; GO:0031205 endoplasmic reticulum Sec complex; GO:0048408 epidermal growth factor binding; GO:0055085 transmembrane transport