IgE antibody | huMaE11
Human anti IgE (Omalizumab Biosimilar)
- Product Type
- Monoclonal Antibody
|Human Anti-IgE Antibody, clone huMaE11 is a research grade biosimilar of the monoclonal antibody drug omalizumab. This product is supplied in a research grade format, i.e. in PBS buffer with preservative, it is not manufactured or formulated in the same way as the therapeutic reference product. A preservative free version is available on request.
This product is a recombinant human IgG1 kappa antibody with variable regions from the therapeutic antibody omalizumab.
Human Anti-IgE Antibody is for research use only. It is suitable as a reference standard in a pharmacokinetic (PK) bridging ELISA with anti-omalizumab antibodies, for example HCA235P and HCA236. It can also be used as capture and detection reagent in an anti-drug antibody (ADA) bridging ELISA, with an anti-omalizumab antibody in IgG1 format as reference standard, for example HCA235.
Omalizumab (Xolair) is a recombinant humanized IgG1 kappa monoclonal antibody used in the treatment of patients with moderate or severe asthma. Allergic asthma is mediated by immunoglobulin E (IgE) released by B cells in response to allergen. Circulating IgE binds to the high-affinity IgE Fc receptor (FcεRI) expressed on basophils and mast cells, triggering the release of histamine, leukotrienes and other mediators associated with the pathophysiology of asthma. Omalizumab is directed against the Fc region of human IgE. By binding to circulating IgE at the site of FcεRI binding, this therapeutic antibody prevents the interaction of IgE with its receptor thus limiting mediator release.
This product is NOT FOR THERAPEUTIC USE.
View a summary of supporting anti-omalizumab antibody products
- Target Species
- Product Form
- Human IgG1 (kappa) antibody - liquid
- Purified recombinant IgG prepared by affinity chromatography on Protein A from a mammalian cell line
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.02% Proclin 300
- Human IgE protein
- >98% by SDS PAGE
- Approx. Protein Concentrations
- IgG concentration 1.0 mg/ml
- For research purposes only
- 12 months from date of despatch
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
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- Licensed Use
- For in vitro research purposes only. Research grade biosimilar. Not for use in therapeutic or diagnostic procedures for humans or animals.
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