IgE antibody | huMaE11

Human anti IgE (Omalizumab Biosimilar)

Product Type
Monoclonal Antibody
Clone
huMaE11
Isotype
IgG1
Specificity
IgE

Product Code Applications Pack Size List Price Your Price Qty
MCA6105
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SDS Safety Datasheet SDS
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Human Anti-IgE Antibody, clone huMaE11 is a research grade biosimilar of the monoclonal antibody drug omalizumab. This product is supplied in a research grade format, i.e. in PBS buffer with preservative, it is not manufactured or formulated in the same way as the therapeutic reference product. A preservative free version is available on request.

This product is a recombinant human IgG1 kappa antibody with variable regions from the therapeutic antibody omalizumab.

Human Anti-IgE Antibody is for research use only. It is suitable as a reference standard in a pharmacokinetic (PK) bridging ELISA with anti-omalizumab antibodies, for example HCA235P and HCA236. It can also be used as capture and detection reagent in an anti-drug antibody (ADA) bridging ELISA, with an anti-omalizumab antibody in IgG1 format as reference standard, for example HCA235.

Omalizumab (Xolair) is a recombinant humanized IgG1 kappa monoclonal antibody used in the treatment of patients with moderate or severe asthma. Allergic asthma is mediated by immunoglobulin E (IgE) released by B cells in response to allergen. Circulating IgE binds to the high-affinity IgE Fc receptor (FcεRI) expressed on basophils and mast cells, triggering the release of histamine, leukotrienes and other mediators associated with the pathophysiology of asthma. Omalizumab is directed against the Fc region of human IgE. By binding to circulating IgE at the site of FcεRI binding, this therapeutic antibody prevents the interaction of IgE with its receptor thus limiting mediator release.

This product is NOT FOR THERAPEUTIC USE.

View a summary of supporting anti-omalizumab antibody products

Target Species
Human
Product Form
Human IgG1 (kappa) antibody - liquid
Preparation
Purified recombinant IgG prepared by affinity chromatography on Protein A from a mammalian cell line
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.02% Proclin 300
Immunogen
Human IgE protein
Purity
>98% by SDS PAGE
Approx. Protein Concentrations
IgG concentration 1.0 mg/ml
Regulatory
For research purposes only
Guarantee
12 months from date of despatch

This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.

Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
ELISA
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.

Description Product Code Applications Pack Size List Price Your Price Quantity
Hispec Assay Diluent BUF049A E IY 50 ml
List Price Your Price
Description Hispec Assay Diluent

Licensed Use
For in vitro research purposes only. Research grade biosimilar. Not for use in therapeutic or diagnostic procedures for humans or animals.
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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