CD282 antibody | 11G7
Mouse anti Human CD282:Alexa Fluor® 647
- Product Type
- Monoclonal Antibody
- Clone
- 11G7
- Isotype
- IgG1
- Specificity
- CD282
Mouse anti Human CD282 antibody, clone 11G7 recognizes the human Toll-like receptor 2 (TLR2), a ~90 kDa type 1 transmembrane protein that is primarily expressed by peripheral blood monocytes. TLR2, also known as CD282, is reported to respond to a diverse range of bacterial cell wall components, mediating the innate immune response in co-operation with MD-2. Mouse anti Human CD282 antibody, clone 11G7 has been reported to block IL-6 cytokine production in response to ara-lipoarabinomannan (araLAM) and tripalmitoyl cysteinyl lipopeptide (Pam3CSK4) (Sandor et al. 2003). Clone 11G7 does not inhibit the production of cytokines induced by zymosan stimulation. |
- Target Species
- Human
- Product Form
- MCA2484A647: Purified IgG conjugated to Alexa Fluor® 647 - liquid
- MCA2484A647T: Purified IgG conjugated to Alexa Fluor®647 - liquid
- Preparation
- MCA2484A647: Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
- MCA2484A647T: Purified IgG prepared by affinity chromatography on Protein A from tissue culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
0.09% Sodium Azide (NaN3) 1% Bovine Serum Albumin - Approx. Protein Concentrations
- IgG concentration 0.05mg/ml
- Max Ex/Em
-
Fluorophore Excitation Max (nm) Emission Max (nm) Alexa Fluor®647 650 665 - Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
- Acknowledgements
- This product is provided under an intellectual property licence from Life Technologies Corporation. The transfer of this product is contingent on the buyer using the purchase product solely in research, excluding contract research or any fee for service research, and the buyer must not sell or otherwise transfer this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; (c) manufacturing or quality assurance or quality control, or (d) resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5791 Van Allen Way, Carlsbad CA 92008 USA or outlicensing@thermofisher.com
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended. This product is photosensitive and should be protected from light.
Application Name | Verified | Min Dilution | Max Dilution |
---|---|---|---|
Flow Cytometry | Neat | 1/10 |
- Flow Cytometry
- Use 10ul of the suggested working dilution to label 1x106 cells in 100ul.
Description | Product Code | Applications | Pack Size | List Price | Your Price | Quantity | |
---|---|---|---|---|---|---|---|
Mouse IgG1 Negative Control:Alexa Fluor® 647 | MCA928A647 | F | 100 Tests/1ml | Log in | |||
List Price | Your Price | ||||||
Log in | |||||||
Description | Mouse IgG1 Negative Control:Alexa Fluor® 647 |
Description | Product Code | Applications | Pack Size | List Price | Your Price | Quantity | |
---|---|---|---|---|---|---|---|
Human Seroblock | BUF070A | F | 50 Test | Log in | |||
List Price | Your Price | ||||||
Log in | |||||||
Description | Human Seroblock | ||||||
Human Seroblock | BUF070B | F | 200 Test | Log in | |||
List Price | Your Price | ||||||
Log in | |||||||
Description | Human Seroblock |
References for CD282 antibody
-
Sandor, F. et al. (2003) Importance of extra- and intracellular domains of TLR1 and TLR2 in NFkappa B signaling.
J Cell Biol. 162 (6): 1099-110. -
Royer, P.J. et al. (2010) The mannose receptor mediates the uptake of diverse native allergens by dendritic cells and determines allergen-induced T cell polarization through modulation of IDO activity.
J Immunol. 185 (3): 1522-31. -
Chen, E.S. et al. (2010) Serum amyloid A regulates granulomatous inflammation in sarcoidosis through Toll-like receptor-2.
Am J Respir Crit Care Med. 181 (4): 360-73. -
Royer, P.J. et al. (2010) The mannose receptor mediates the uptake of diverse native allergens by dendritic cells and determines allergen-induced T cell polarization through modulation of IDO activity.
J Immunol. 185 (3): 1522-31. -
Zhou, S. et al. (2010) Discovery of a novel TLR2 signaling inhibitor with anti-viral activity.
Antiviral Res. 87 (3): 295-306. -
Nguyen, D.N. et al. (2016) Oral antibiotics increase blood neutrophil maturation and reduce bacteremia and necrotizing enterocolitis in the immediate postnatal period of preterm pigs.
Innate Immun. 22 (1): 51-62.
- Synonyms
- TLR2
- RRID
- AB_1101735
- UniProt
- O60603
- Entrez Gene
- TLR2
- GO Terms
- GO:0001875 lipopolysaccharide receptor activity
- GO:0002755 MyD88-dependent toll-like receptor signaling pathway
- GO:0004888 transmembrane receptor activity
- GO:0005887 integral to plasma membrane
- GO:0005737 cytoplasm
- GO:0006917 induction of apoptosis
- GO:0006954 inflammatory response
- GO:0007252 I-kappaB phosphorylation
- GO:0008063 Toll signaling pathway
- View More GO Terms
- GO:0010552 positive regulation of gene-specific transcription from RNA polymerase II promoter
- GO:0030177 positive regulation of Wnt receptor signaling pathway
- GO:0032722 positive regulation of chemokine production
- GO:0032728 positive regulation of interferon-beta production
- GO:0032735 positive regulation of interleukin-12 production
- GO:0032741 positive regulation of interleukin-18 production
- GO:0032755 positive regulation of interleukin-6 production
- GO:0032757 positive regulation of interleukin-8 production
- GO:0032760 positive regulation of tumor necrosis factor production
- GO:0034123 positive regulation of toll-like receptor signaling pathway
- GO:0034130 toll-like receptor 1 signaling pathway
- GO:0034134 toll-like receptor 2 signaling pathway
- GO:0034142 toll-like receptor 4 signaling pathway
- GO:0035354 Toll-like receptor 1-Toll-like receptor 2 protein complex
- GO:0042346 positive regulation of NF-kappaB import into nucleus
- GO:0042495 detection of triacyl bacterial lipopeptide
- GO:0042496 detection of diacyl bacterial lipopeptide
- GO:0042497 triacyl lipopeptide binding
- GO:0042834 peptidoglycan binding
- GO:0045087 innate immune response
- GO:0046982 protein heterodimerization activity
- GO:0050729 positive regulation of inflammatory response
- GO:0051092 positive regulation of NF-kappaB transcription factor activity
- GO:0051637 Gram-positive bacterial cell surface binding
- GO:0051770 positive regulation of nitric-oxide synthase biosynthetic process
- GO:0071223 cellular response to lipoteichoic acid
- GO:0071726 cellular response to diacyl bacterial lipopeptide
- GO:0071727 cellular response to triacyl bacterial lipopeptide
MCA2484A647
150001MCA2484A647T
153813If you cannot find the batch/lot you are looking for please contact our technical support team for assistance.
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