BIRC3 antibody | K01/2A8

Mouse anti BIRC3

Product Type
PrecisionAb Monoclonal
Clone
K01/2A8
Isotype
IgG2a
Format
Purified
Specificity
BIRC3

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MCA6173
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Mouse anti BIRC3 antibody recognizes baculoviral IAP repeat-containing protein 3, also known as cIAP2, apoptosis inhibitor 2, IAP homolog C, and RING finger protein 49.

BIRC3 belongs to the IAP family of proteins, comprising eight members which share a BIR domain. IAP proteins act as E3 ligases and are known for their role in regulators of caspases and cell death, thereby controlling a diverse range of cellular processes (Silke and Meier 2013). Accordingly, BIRC3 is an apoptosis inhibitor, and overexpression or disruption of BIRC3 has been implicated in many cancer types (Wang et al. 2019) including oral squamous cell carcinoma, glioblastoma, and pancratic cancer. BIRC3 is also a significant regulator of the NF-κB signaling pathway, and through NF-κB signaling, contributes to hepatocellular carcinoma (HCC) development (Cao et al. 2018).
PrecisionAb Antibodies

Target Species
Human
Western Blotting
Mouse anti BIRC3 antibody detects a band of approximately 74 kDa in Raji cell lysates
Product Form
Purified IgG - liquid
Preparation
Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.09% Sodium Azide (NaN3)
Immunogen
E. coli-derived recombinant protein, aa 1-604 of human BIRC3
Approx. Protein Concentrations
IgG concentration 1.0 mg/ml
Regulatory
For research purposes only
Guarantee
12 months from date of despatch
Acknowledgements
PrecisionAb is a trademark of Bio-Rad Laboratories

Store undiluted at -20°C, avoiding repeated freeze thaw cycles

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Immunoprecipitation
Western Blotting 1/1000

The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.

UniProt
Q13489
Entrez Gene
BIRC3
GO Terms
GO:0005515 protein binding
GO:0006915 apoptosis
GO:0004842 ubiquitin-protein ligase activity
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0006916 anti-apoptosis
GO:0007166 cell surface receptor linked signaling pathway
GO:0008270 zinc ion binding
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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