Human cardiac troponin I
is the inhibitory subunit of troponin involved in confering calcium sensitivity to muscle actomyosin ATPase activity. Mutation of the TNN13 gene can lead to familial hypotrophic cardiomyopathy 7 (CMH7
), a hereditary heart condition characterized by asymetric ventricular hypertrophy (Kimura et al. 1997
). Other cardiomyopathies also occur as a result of mutations in the TNN13 gene (UniProt : P19429
- Target Species
- Product Form
- Purified protein from human heart - liquid
- Buffer Solution
- 7M Urea
- Preservative Stabilisers
- 15mM Mercaptoethanol
- SDS PAGE: >98%
- Approx. Protein Concentrations
- 1.0 mg/ml
- Store at -20oC only.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the protein. Should this product contain a precipitate we recommend microcentrifugation before use.
- 12 months from date of despatch
- Entrez Gene
- GO Terms
regulation of systemic arterial blood pressure by ischemic conditions
cellular calcium ion homeostasis
calcium channel inhibitor activity
protein kinase binding
protein domain specific binding
muscle filament sliding
troponin C binding
troponin T binding
negative regulation of ATPase activity
calcium-dependent protein binding
ventricular cardiac muscle tissue morphogenesis
cardiac muscle contraction
- For research purposes only
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Applications of Troponin I
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using the appropriate negative/positive controls.
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