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Troponin I

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Native Human Troponin I (Cardiac)

Product Type
Purified Protein
Specificity
Troponin I
Region
(CARDIAC)

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Product Code Applications Pack Size List Price Your Price Qty
9202-0707
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Human cardiac troponin I is the inhibitory subunit of troponin involved in confering calcium sensitivity to muscle actomyosin ATPase activity. Mutation of the TNN13 gene can lead to familial hypotrophic cardiomyopathy 7 (CMH7), a hereditary heart condition characterized by asymetric ventricular hypertrophy (Kimura et al. 1997). Other cardiomyopathies also occur as a result of mutations in the TNN13 gene (UniProt : P19429).

Target Species
Human
Product Form
Purified protein from human heart - liquid
Buffer Solution
7M Urea
5mM EDTA
20mM Tris
Preservative Stabilisers
15mM Mercaptoethanol
Purity
SDS PAGE: >98%
Approx. Protein Concentrations
1.0 mg/ml
Regulatory
For research purposes only
Guarantee
12 months from date of despatch

Store at -20oC only.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the protein. Should this product contain a precipitate we recommend microcentrifugation before use.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
ELISA
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using the appropriate negative/positive controls.

References for Troponin I

  1. Sharma, A. et al. (2016) Rapid electrical immunoassay of the cardiac biomarker troponin I through dielectrophoretic concentration using imbedded electrodes
    Biosensors and Bioelectronics. 82: 78-84.

UniProt
P19429
Entrez Gene
TNNI3
GO Terms
GO:0001570 vasculogenesis
GO:0001980 regulation of systemic arterial blood pressure by ischemic conditions
GO:0003779 actin binding
GO:0005829 cytosol
GO:0005861 troponin complex
GO:0006874 cellular calcium ion homeostasis
GO:0019855 calcium channel inhibitor activity
GO:0019901 protein kinase binding
GO:0019904 protein domain specific binding
GO:0030049 muscle filament sliding
GO:0030172 troponin C binding
GO:0031014 troponin T binding
GO:0032780 negative regulation of ATPase activity
GO:0048306 calcium-dependent protein binding
GO:0055010 ventricular cardiac muscle tissue morphogenesis
GO:0060048 cardiac muscle contraction

9202-0707

153758 154463

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