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Thyroglobulin

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Sandwich ELISA analysis of human thyroglobulin using Mouse anti Human thyroglobulin , clone 5F9 (8900-0700) as a capture reagent and biotinylated Mouse anti Human thyroglobulin, clone 5E6 as a detection reagent with purified human thyroglobulin as antigen (PHP236) for production of a standard curve. Detection is by HRP conjugated streptavidin. Microtitre plate is read at O.D. 450 nm on the Bio-Rad iMark Microplate Absorbance Reader (Bio-Rad Catalog 168-1135). Serum samples (green and blue) and plasma samples (orange and red) are shown.

Native Human Thyroglobulin

Product Type
Purified Protein
Specificity
Thyroglobulin

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PHP236
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Purified Human Thyroglobulin is derived from human thyroid glands and is the precursor of thyroxine (T3) and triiodothyronine (T4). Thyroglobulin is a 2768 amino acid secreted glycoprotein with a 19 aa N-terminal signal peptide, made within and targeted to the thyroid.

Mutations of the TG gene may lead to the development of Thyroid dyshormonogenesis 3 (TDH3) a condition presenting with predominant goiters on the majority of patients and may lead to varying degrees of neurologic and intellectual defects. Variations in the TG gene may also result in increased susceptibility to the development of Autoimmune thyroid disease 3 (AITD3), an autoimmune disorder comprised of two related diseases of the thyroid: Graves disease and Hashimoto thyroditis (Caturegli et al. 2014).

Target Species
Human
Product Form
Purified protein from human thyroid glands - liquid
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
None present
Purity
SDS PAGE: >98%, ultra-pure, IgG low
Approx. Protein Concentrations
1.0 mg/ml
Protein Molecular Weight
660 kDa by chromatography and electrophoresis, under certain conditions the 330 kDa subunit may be observed.
Regulatory
For research purposes only
Guarantee
12 months from date of despatch

Store at -20oC only.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the protein. Should this product contain a precipitate we recommend microcentrifugation before use.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
ELISA
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using the appropriate negative/positive controls.

References for Thyroglobulin

  1. Smith, M.J. et al. (2018) Activation of thyroid antigen-reactive B cells in recent onset autoimmune thyroid disease patients.
    J Autoimmun. 89: 82-89.

Synonyms
Tg
UniProt
P01266
Entrez Gene
TG

PHP236

146855 162302 180322

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