C3 is a complement protein that is activated through cleavage by complement 3 (C3) convertases to C3a and C3b. These are further degraded into iC3b and C3dg/C3d. C3 is crucial in the induction of tolerance generated when an antigen is introduced into immunoprivileged sites and this is exploited by pathogens and cancer cells to evade the immune system by inhibiting complement activation.
- Target Species
- Product Form
- Purified human C3 - liquid
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- None present
- >85% by SDS PAGE
- Approx. Protein Concentrations
- Please see label for concentration
- Store at -70oC.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the protein. Should this product contain a precipitate we recommend microcentrifugation before use.
- Guaranteed until date of expiry. Please see product label.
- Entrez Gene
- GO Terms
endopeptidase inhibitor activity
complement activation, alternative pathway
complement activation, classical pathway
G-protein coupled receptor protein signaling pathway
positive regulation vascular endothelial growth factor production
- For research purposes only
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
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