C3

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Purified Human C3

Product Type: Purified Protein

Product Code	Applications	Pack Size	Your Price	List Price	Quantity
PHP283 Datasheet	E SDS	0.25 mg	Log in		Get Quote

Summary
Spectraviewer

C3 is a complement protein that is activated through cleavage by complement 3 (C3) convertases to C3a and C3b. These are further degraded into iC3b and C3dg/C3d. C3 is crucial in the induction of tolerance generated when an antigen is introduced into immunoprivileged sites and this is exploited by pathogens and cancer cells to evade the immune system by inhibiting complement activation.

Product Details

Target Species: Human
Product Form: Purified human C3 - liquid
Buffer Solution: Phosphate buffered saline
Preservative Stabilisers: None present
Purity: >85% by SDS PAGE
Approx. Protein Concentrations: Current, batch-specific concentration 1.11 mg/ml

Storage Information

Storage: Store at -70^oC.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the protein. Should this product contain a precipitate we recommend microcentrifugation before use.
Guarantee: Guaranteed until date of expiry. Please see product label.

More Information

UniProt: P01024
Entrez Gene: C3
GO Terms: GO:0005102 receptor binding; GO:0004866 endopeptidase inhibitor activity; GO:0005615 extracellular space; GO:0006954 inflammatory response; GO:0006957 complement activation, alternative pathway; GO:0006958 complement activation, classical pathway; GO:0007186 G-protein coupled receptor protein signaling pathway; GO:0010575 positive regulation vascular endothelial growth factor production
Regulatory: For research purposes only

Applications of C3

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.

Application Name	Verified	Min Dilution	Max Dilution
ELISA

Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.

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