|Recombinant Chicken interleukin-1 (IL-1) is a pro-inflammatory cytokine secreted by many different cell types acting on a wide range of target cells, resulting in a diverse range of effects. The biological properties of IL-1 include the induction of B cell proliferation, stimulation of T cell proliferation in conjunction with IL-2 and the production of collagenase and prostaglandin by fibroblasts. IL-1 is also responsible for triggering the acute-phase response in the liver, and is involved in both cytokine network and vascular endothelium activation. Recombinant Chicken interleukin-1 (PAP002) induces corticosterone secretion in vivo (Weining et al. 1992).
Recombinant Chicken interleukin-1 (PAP002) was the immunogen used to produce Bio-Rad chicken IL-1beta antibody (AHP941Z).
- Target Species
- Product Form
- Purified His-tagged recombinant protein expressed in E.coli - liquid
- Recombinant protein prepared from E.coli
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- None present
- >85% by Ni chelate Chromatography
- Approx. Protein Concentrations
- 250 ug/ml
- Protein Molecular Weight
- approximately 23kD
- For research purposes only
- 3 months from date of despatch
- His-tag is a registered trademark of EMD Biosciences.
Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the protein. Should this product contain a precipitate we recommend microcentrifugation before use.
|Application Name||Verified||Min Dilution||Max Dilution|
|In vitro Assay|
References for IL-1 Beta
Weining, K.C. et al. (1998) A chicken homolog of mammalian interleukin-1 beta: cDNA cloning and purification of active recombinant protein.
Eur J Biochem. 258 (3): 994-1000.
Gyorfy, Z. et al. (2003) Truncated chicken interleukin-1beta with increased biologic activity.
J Interferon Cytokine Res. 23 (5): 223-8.
Abdel-mageed, A.M. et al. (2017) Modulatory roles of proinflammatory cytokines on the expression of cathelicidins in the lower regions of the oviduct of laying hens.
Cytokine. 99: 66-72.
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