IL-1 Beta
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Recombinant Chicken interleukin-1 (IL-1) is a pro-inflammatory cytokine secreted by many different cell types acting on a wide range of target cells, resulting in a diverse range of effects. The biological properties of IL-1 include the induction of B cell proliferation, stimulation of T cell proliferation in conjunction with IL-2 and the production of collagenase and prostaglandin by fibroblasts. IL-1 is also responsible for triggering the acute-phase response in the liver, and is involved in both cytokine network and vascular endothelium activation. Recombinant Chicken interleukin-1 (PAP002) induces corticosterone secretion in vivo (Weining et al. 1992).
Recombinant Chicken interleukin-1 (PAP002) was the immunogen used to produce Bio-Rad chicken IL-1beta antibody (AHP941Z).
Recombinant Chicken interleukin-1 (PAP002) was the immunogen used to produce Bio-Rad chicken IL-1beta antibody (AHP941Z).
Product Details
- Target Species
- Chicken
- Product Form
- Purified His-tagged recombinant protein expressed in E.coli - liquid
- Preparation
- Recombinant protein prepared from E.coli
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- None present
- Purity
- >85% by Ni chelate Chromatography
- Approx. Protein Concentrations
- 250 ug/ml
- Protein Molecular Weight
- approximately 23kD
Storage Information
- Storage
- Store at -20oC only.
Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the protein. Should this product contain a precipitate we recommend microcentrifugation before use. - Shelf Life
- 3 months from date of despatch.
More Information
- UniProt
- O73909 Related reagents
- Acknowledgements
- His-tag is a registered trademark of EMD Biosciences.
- Regulatory
- For research purposes only
Applications of IL-1 Beta
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Functional Assays | |||
| In vitro Assay |
Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls.
Copyright © 2018 Bio-Rad Antibodies (formerly AbD Serotec)
Product Specific References
References for IL-1 Beta
-
Weining, K.C. et al. (1998) A chicken homolog of mammalian interleukin-1 beta: cDNA cloning and purification of active recombinant protein.
Eur J Biochem. 258 (3): 994-1000. -
Gyorfy, Z. et al. (2003) Truncated chicken interleukin-1beta with increased biologic activity.
J Interferon Cytokine Res. 23 (5): 223-8. -
Abdel-mageed, A.M. et al. (2017) Modulatory roles of proinflammatory cytokines on the expression of cathelicidins in the lower regions of the oviduct of laying hens.
Cytokine. 99: 66-72.
