IL-1 Beta

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Recombinant Chicken Interleukin-1 beta

Product Type: Recombinant Protein
Specificity: IL-1 Beta

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References (3)
Applications
Storage Information
Batch/Lot Specific Datasheets

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PAP002 Datasheet Datasheet SDS SDS	FN IA	50 µg		Log in	Get Quote
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Recombinant Chicken interleukin-1 (IL-1) is a pro-inflammatory cytokine secreted by many different cell types acting on a wide range of target cells, resulting in a diverse range of effects. The biological properties of IL-1 include the induction of B cell proliferation, stimulation of T cell proliferation in conjunction with IL-2 and the production of collagenase and prostaglandin by fibroblasts. IL-1 is also responsible for triggering the acute-phase response in the liver, and is involved in both cytokine network and vascular endothelium activation. Recombinant Chicken interleukin-1 (PAP002) induces corticosterone secretion in vivo (Weining et al. 1992).

Recombinant Chicken interleukin-1 (PAP002) was the immunogen used to produce Bio-Rad chicken IL-1beta antibody (AHP941Z).

Target Species: Chicken
Product Form: Purified His-tagged recombinant protein expressed in E.coli - liquid
Preparation: Recombinant protein prepared from E.coli
Source: E.coli
Buffer Solution: Phosphate buffered saline
Preservative Stabilisers: None present
Purity: >85% by Ni chelate Chromatography
Approx. Protein Concentrations: 250 ug/ml
Protein Molecular Weight: approximately 23kD
Regulatory: For research purposes only
Guarantee: 3 months from date of despatch
Acknowledgements: His-tag is a registered trademark of EMD Biosciences.

Store at -20^oC only.
Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the protein. Should this product contain a precipitate we recommend microcentrifugation before use.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.

Application Name	Verified	Min Dilution	Max Dilution
Functional Assays
In vitro Assay

Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.

References for IL-1 Beta

Weining, K.C. et al. (1998) A chicken homolog of mammalian interleukin-1 beta: cDNA cloning and purification of active recombinant protein.
Eur J Biochem. 258 (3): 994-1000.
Gyorfy, Z. et al. (2003) Truncated chicken interleukin-1beta with increased biologic activity.
J Interferon Cytokine Res. 23 (5): 223-8.
Abdel-mageed, A.M. et al. (2017) Modulatory roles of proinflammatory cytokines on the expression of cathelicidins in the lower regions of the oviduct of laying hens.
Cytokine. 99: 66-72.