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|Recombinant Chicken interferon alpha (IFN alpha) shares structural and biological properties with mammalian IFN1. Recombinant chicken IFN alpha (rChIFNa) has been shown to act as a highly potent anti-viral agent in vitro (Schultz, U. et al. 1995). rChIFNa also resulted in a noticeable delay in the progression of tumors in CC progressor chickens infected with Rous Sarcoma Virus, when administered intravenously (Plachy, J. et al. 1999).
Recombinant chicken interferon alpha is the immunogen used to produce the polyclonal Rabbit anti Chicken interferon alpha antibody.
- Target Species
- Product Form
- Purified recombinant protein expressed in E.coli - liquid.
- Recombinant protein prepared from E.coli
- Buffer Solution
- 0.05M Sodium Acetate
1M Sodium Chloride
- Preservative Stabilisers
- None present
- >85% by Ni chelate chromatography
- Approx. Protein Concentrations
- Total protein concentration 1.0 mg/ml
- Protein Molecular Weight
- 19 kD
- For research purposes only
- 3 months from date of despatch
Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the protein.
This product should be stored undiluted.
Should this product contain a precipitate we recommend microcentrifugation before use.
|Application Name||Verified||Min Dilution||Max Dilution|
References for IFN Alpha
Schultz, U. et al. (1995) Recombinant chicken interferon: a potent antiviral agent that lacks intrinsic macrophage activating factor activity.
Eur J Immunol. 25 (3): 847-51.
Plachy, J. et al. (1999) Protective effects of Type I and Type II interferons toward Rous Sarcoma Virus-induced tumors in chickens.
Virology. 256: 85-91.
Schwarz, H. et al. (2004) Synthesis of IFN-beta by virus-infected chicken embryo cells demonstrated with specific antisera and a new bioassay.
J Interferon Cytokine Res. 24 (3): 179-84.
Schultz, U. et al. (1995) Recombinant chicken interferon from Escherichia coli and transfected COS cells is biologically active.
Eur J Biochem. 229 (1): 73-6.
Jiang, H. et al. (2011) Chicken interferon alpha pretreatment reduces virus replication of pandemic H1N1 and H5N9 avian influenza viruses in lung cell cultures from different avian species.
Virol J. 8: 447.
Smith, S.E. et al. (2013) Chicken interferon-inducible transmembrane protein 3 restricts influenza viruses and lyssa viruses in vitro.
J Virol. 87 (23): 12957-66.
Alamares, J.G. et al. (2010) The interferon antagonistic activities of the V proteins from two strains of Newcastle disease virus correlate with their known virulence properties.
Virus Res. 147 (1): 153-7.
Lostalé-seijo, I. et al. (2016) Interferon induction by avian reovirus.
Virology. 487: 104-11.
View The Latest Product References
Lostalé-seijo, I. et al. (2016) Response of Three Different Viruses to Interferon Priming and Dithiothreitol Treatment of Avian Cells.
J Virol. 90 (18): 8328-40.
Deng, L. et al. (2016) Characterization and functional studies of fowl adenovirus 9 dUTPase.
Virology. 497: 251-61.
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