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Sheep anti Human C1q:FITC
- Product Type
- Polyclonal Antibody
- Polyclonal IgG
|Sheep anti Human C1q antibody recognizes human C1q, a sub-component of the C1 complement component.|
- Target Species
- Product Form
- Purified IgG conjugated to Fluorescein Isothiocyanate Isomer 1 (FITC) - liquid
- Antiserum Preparation
- Antisera to human C1q were raised by repeated immunisation of sheep with highly purified antigen. Purified IgG was prepared from whole serum by ion exchange chromatography.
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- <0.1% Sodium Azide (NaN3)
- Human C1q, purified from plasma.
- Approx. Protein Concentrations
- IgG concentration 10 mg/ml
- Max Ex/Em
Fluorophore Excitation Max (nm) Emission Max (nm) FITC 490 525
- For research purposes only
- 12 months from date of despatch
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended. This product is photosensitive and should be protected from light.
|Application Name||Verified||Min Dilution||Max Dilution|
|Immunohistology - Frozen||1/25||1/50|
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References for C1q antibody
John, M. et al. (2000) Nephrotic syndrome in a patient with IgA deficiency-associated mesangioproliferative glomerulonephritis.
Pathology. 32 (1): 56-8.
Sárvári, M. et al. (2003) Inhibition of C1q-beta-amyloid binding protects hippocampal cells against complement mediated toxicity.
J Neuroimmunol. 137: 12-8.
Cragg, M.S. and Glennie, M.J. (2004) Antibody specificity controls in vivo effector mechanisms of anti-CD20 reagents.
Blood. 103: 2738-43.
Yuste, J. et al. (2007) Serum amyloid P aids complement-mediated immunity to Streptococcus pneumoniae.
PLoS Pathog. 3: 1208-19.
Lewis, M.J. et al. (2008) The different effector function capabilities of the seven equine IgG subclasses have implications for vaccine strategies.
Mol Immunol. 45: 818-27.
Hwang, H.Y. et al. (2008) Highly specific inhibition of C1q globular-head binding to human IgG: a novel approach to control and regulate the classical complement pathway using an engineered single chain antibody variable fragment.
Mol Immunol. 45: 2570-80.
Tang, Z. et al. (2013) A human single-domain antibody elicits potent antitumor activity by targeting an epitope in mesothelin close to the cancer cell surface.
Mol Cancer Ther. 12: 416-26.
Ramos-sevillano, E. et al. (2015) Pleiotropic effects of cell wall amidase LytA on Streptococcus pneumoniae sensitivity to the host immune response.
Infect Immun. 83 (2): 591-603.
View The Latest Product References
- Complement Component 1q
- Entrez Gene
- GO Terms
- GO:0005602 complement component C1 complex
- GO:0006958 complement activation, classical pathway
- GO:0007267 cell-cell signaling
- GO:0045087 innate immune response
- GO:0005576 extracellular region
- GO:0030853 negative regulation of granulocyte differentiation
- GO:0045650 negative regulation of macrophage differentiation
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