C1q antibody
Product Details
- Target Species
- Human
- Product Form
- Purified IgG conjugated to Fluorescein Isothiocyanate Isomer 1 (FITC) - liquid
- Product Form
- Purified IgG - liquid
- Antiserum Preparation
- Antisera to human C1q were raised by repeated immunisation of sheep with highly purified antigen. Purified IgG was prepared from whole serum by ion exchange chromatography.
- Buffer Solution
- Phosphate buffered saline
- Buffer Solution
- Glycine buffered saline
- Preservative Stabilisers
0.09% Sodium Azide - Preservative Stabilisers
0.09% Sodium Azide 0.1% EACA 0.01% Benzamidine 1mM EDTA - Immunogen
- Human C1q, purified from plasma.
- Approx. Protein Concentrations
- IgG concentration 10 mg/ml
Storage Information
- Storage
- Store at +4oC or at -20oC if preferred.
This product should be stored undiluted.
Storage in frost free freezers is not recommended. This product is photosensitive and should be protected from light.
Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. - Storage
- Store at +4oC or at -20oC if preferred.
This product should be stored undiluted.
Storage in frost free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. - Guarantee
- 12 months from date of despatch
- Guarantee
- Guaranteed until date of expiry. Please see product label.
More Information
- UniProt
- P02747
- P02745
- P02746
- Entrez Gene
- C1QA
- C1QB
- C1QC
- GO Terms
- GO:0005602 complement component C1 complex
- GO:0006958 complement activation, classical pathway
- GO:0007267 cell-cell signaling
- GO:0045087 innate immune response
- GO:0005576 extracellular region
- GO:0030853 negative regulation of granulocyte differentiation
- GO:0045650 negative regulation of macrophage differentiation
- Regulatory
- For research purposes only
Applications of C1q antibody
Application Name | Verified | Min Dilution | Max Dilution |
---|---|---|---|
Immunohistology - Frozen | 1/25 | 1/50 | |
ELISA | |||
Flow Cytometry | |||
Immunodiffusion | Neat |
Secondary Antibodies Available
Description | Product Code | Applications | Pack Size | List Price | Quantity |
---|---|---|---|---|---|
Rabbit anti Sheep IgG (H/L):Biotin | 5184-2304 | C E F WB | 1.5 ml |
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Donkey anti Sheep/Goat IgG:DyLight®488 | STAR88D488GA | F IF | 0.1 mg |
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Donkey anti Sheep/Goat IgG:FITC | STAR88F | C | 1 mg |
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Donkey anti Sheep/Goat IgG:HRP | STAR88P | C E P WB | 1 ml |
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Product Specific References
References for C1q antibody
-
Hwang, H.Y. et al. (2008) Highly specific inhibition of C1q globular-head binding to human IgG: a novel approach to control and regulate the classical complement pathway using an engineered single chain antibody variable fragment.
Mol Immunol. 45: 2570-80. -
Cragg, M.S. and Glennie, M.J. (2004) Antibody specificity controls in vivo effector mechanisms of anti-CD20 reagents.
Blood. 103: 2738-43. -
Sárvári, M. et al. (2003) Inhibition of C1q-beta-amyloid binding protects hippocampal cells against complement mediated toxicity.
J Neuroimmunol. 137: 12-8. -
Lewis, M.J. et al. (2008) The different effector function capabilities of the seven equine IgG subclasses have implications for vaccine strategies.
Mol Immunol. 45: 818-27. -
Yuste, J. et al. (2007) Serum amyloid P aids complement-mediated immunity to Streptococcus pneumoniae.
PLoS Pathog. 3: 1208-19. -
Tang, Z. et al. (2013) A human single-domain antibody elicits potent antitumor activity by targeting an epitope in mesothelin close to the cancer cell surface.
Mol Cancer Ther. 12: 416-26. -
John, M. et al. (2000) Nephrotic syndrome in a patient with IgA deficiency-associated mesangioproliferative glomerulonephritis.
Pathology. 32 (1): 56-8. -
Ramos-sevillano, E. et al. (2015) Pleiotropic effects of cell wall amidase LytA on Streptococcus pneumoniae sensitivity to the host immune response.
Infect Immun. 83 (2): 591-603.
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