We offer a comprehensive range of antibodies to neuroscience related biomarkers, ideal for multiple research applications and diagnostic assay development.
One of the significant markers is creatine phosphokinase (CPK or CK), which is an enzyme expressed in tissues and cell types with high energy requirements. CPK serves as an energy reservoir for the rapid buffering, regeneration of ATP, and for intracellular energy transport. Elevated blood level of CPK is an indication of muscle damage, it is therefore indicative of myocardial infarction (heart attack), rhabdomyolysis (severe muscle breakdown), muscular dystrophy and acute renal failure.
Myelin proteolipid protein (PLP) is the major constituent of myelin protein from the central nervous system. The myelin sheath is unique to the nervous system, which insulate the axon from electrical activity and act to increase the rate of transmission of signals. In human, mutations of the PLP have been reported to be associated with dysmyelinating disorders, including the heterogeneous syndromes of Pelizaeus-Merzbacher disease (PMD), a neurologic disorder of myelin metabolism.
Ubiquitin is a small (8.5 kDa) protein that exists in almost all tissues of eukaryotic organisms. It functions as a post-translational modification by attached to the substrate proteins, thereby affecting the proteins in many ways, including signalling for their degradation, affecting their activities, modulating protein interactions, and coordinating the cellular localization.
Anti-ubiquitin antibodies can be used to identify abnormal accumulations of this protein inside cells (inclusion bodies), indicating a disease process. That includes many neurodegenerative diseases, such as neurofibrillary tangles in Alzheimer's disease, Lewy body in Parkinson's disease, Pick bodies in Pick's disease, inclusions in motor neuron disease in Huntington's Disease.