IL-18BP antibody | A07-5D2
Mouse anti Human INTERLEUKIN-18BP:Biotin
- Product Type
- Monoclonal Antibody
- Clone
- A07-5D2
- Isotype
- IgG2b
- Specificity
- IL-18BP
Antibody Quality and Performance Guarantee
| Mouse anti Human interleukin-18BP antibody, clone A07-5D2, recognizes interleukin-18-binidng protein (IL-18BP), also known as tadekinig-alpha. IL-18BP is a secreted immunoregulatory binding protein which binds to and inhibits the cytokine activity of mature IL-18 with high affinity. IL-18 plays a role in host defense, inflammation, tissue repair, and regeneration (Mühl & Bachmann 2019). IL-18BP is constitutively expressed in the spleen, PBMCs, monocytes and umbilical vein endothelial cells (Mühl & Bachmann 2019, Corbaz et al. 2002). It is detectable in the serum of healthy humans at a 20 fold molar excess compared to IL-18, with subjects showing levels of 2,000 – 4,000 pg/ml of IL-18BP (Kaplanski et al. 2018). IL-18BP is upregulated in response to inflammation as part of the inflammation resolution process. Additionally, it can be upregulated during various cancers and IL-18BP levels are also affected by viral infections such as dengue and hepatitis C (Mühl & Bachmann 2019). The biotinylated Mouse anti Human interleukin-18BP antibody, clone A07-5D2 (MCA6245B) can be used as a detection antibody in a sandwich ELISA with the purified Mouse anti Human interleukin-18BP antibody, clone B01-3E12 (MCA6244GA) as the capture antibody. |
- Target Species
- Human
- Product Form
- Purified IgG conjugated to Biotin - liquid
- Preparation
- Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide (NaN3)
1% Bovine Serum Albumin - Immunogen
- NS0 derived recombinant human full length interleukin-18BP (Thr31-Gly194)
- Approx. Protein Concentrations
- IgG concentration 0.1 mg/ml
- Fusion Partners
- Cell fusion between immunized BALB/c mouse spleen cells and mouse myeloma SP2/0
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| ELISA |  |
1.0 ug/ml |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
How to Use the Spectraviewer
Watch the Tool Tutorial Video ▸- Start by selecting the application you are interested in, with the option to select an instrument from the drop down menu or create a customized instrument
- Select the fluorophores or fluorescent proteins you want to include in your panel to check compatibility
- Select the lasers and filters you wish to include
- Select combined or multi-laser view to visualize the spectra
| Description | Product Code | Applications | Pack Size | List Price | Your Price | Quantity | |
|---|---|---|---|---|---|---|---|
| Mouse anti Human INTERLEUKIN-18BP | MCA6244GA | E | 0.1 mg |
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| Description | Mouse anti Human INTERLEUKIN-18BP | ||||||
- UniProt
- O95998
- Entrez Gene
- IL18BP
- GO Terms
- GO:0005576 extracellular region
- GO:0042007 interleukin-18 binding
- GO:0042088 T-helper 1 type immune response
- GO:0048019 receptor antagonist activity
MCA6245B
100005270
If you cannot find the batch/lot you are looking for please contact our technical support team for assistance.
View more products with IL-18 specificity
Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"
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