Mouse anti Human interleukin-17A/F antibody, clone I07-5E4,
recognizes interleukin-17 A and F. The IL-17 family consists of six proteins (IL-17A to IL-17F) which function as proinflammatory cytokines, important for defence against pathogens (Gurczynski and Moore, 2017
). Accordingly, IL-17-producing CD4+
T helper cells, also called Th17 cells, play important roles in immune defense. Uncontrolled IL-17 signaling is associated with immunopathology, autoimmune diseases, and cancer, and blocking activity of IL-17 can be beneficial in some clinical settings (Amatya et al. 2017
). This antibody recognizes IL-17A, the most studied member of the IL-17 family, and its closest relative IL-17F (Chen and Kolls 2017
). These two proteins have similar structure and inflammatory function, but unique functions of IL-17F in the immune system have also been indicated (Chang and Dong, 2009
The biotinylated Mouse anti Human interleukin-17A/F antibody, clone I07-5E4 (MCA6207B) can be used as a detection antibody in a sandwich ELISA with the purified Mouse anti Human interleukin-17A/F antibody, clone D01-1C2 (MCA6206GA
) as the capture antibody.
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Applications of IL-17A/F antibody
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.