CD8 antibody | RPA-T8
Mouse anti Human CD8:FITC
- Product Type
- Monoclonal Antibody
- Clone
- RPA-T8
- Isotype
- IgG1
- Specificity
- CD8
Mouse anti Human CD8 monoclonal antibody, clone RPA-T8 recognizes the alpha-chain of the human CD8 antigen, a ~32 kDa single pass type 1 membrane glycoprotein containing a single Ig-like V-type domain. CD8α forms either homodimers or disulphide bond linked heterodimers with the CD8β chain. CD8 is expressed by thymocytes, the cytotoxic-suppressor subset of T cells and weakly by NK cells. CD8 functions as a receptor for MHC Class I molecules. |
- Target Species
- Human
- Species Cross-Reactivity
-
Target Species Cross Reactivity Chimpanzee Baboon Cynomolgus monkey Rhesus Monkey Macaque - N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Purified IgG conjugated to Fluorescein Isothiocyanate Isomer 1 (FITC) - liquid
- Preparation
- Purified IgG prepared by affinity chromatography
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide (NaN3)
- Approx. Protein Concentrations
- IgG concentration 0.5 mg/ml
- Max Ex/Em
-
Fluorophore Excitation Max (nm) Emission Max (nm) FITC 490 525 - Regulatory
- For research purposes only
- Guarantee
- Guaranteed for 12 months from the date of despatch or until the date of expiry, whichever comes first. Please see label for expiry date.
This product should be stored undiluted. This product is photosensitive and should be protected from light. Should this product contain a precipitate we recommend microcentrifugation before use.
Application Name | Verified | Min Dilution | Max Dilution |
---|---|---|---|
Flow Cytometry | 1/5 | 1/10 |
- Flow Cytometry
- Use 10ul of the suggested working dilution to label 1 x 106 cells or cells or 100ul human whole blood
Description | Product Code | Applications | Pack Size | List Price | Your Price | Quantity | |
---|---|---|---|---|---|---|---|
Mouse IgG1 Negative Control:FITC | MCA928F | F | 100 Tests | Log in | |||
List Price | Your Price | ||||||
Log in | |||||||
Description | Mouse IgG1 Negative Control:FITC |
References for CD8 antibody
-
Morbius, U. (1989) Cluster Report: CD8
inLeukocyte Typing IV, White Cell Differentiation Antigens, edited by Knapp W, Dorken B, Gilks WR, Rieber E, Schmidt RE, Stein H, Von Dem Bome AEG, Oxford University Press: pp 475-8. -
Suranyi, M.G. et al. (1991) Lymphocyte adhesion molecules in T cell-mediated lysis of human kidney cells.
Kidney Int. 39 (2): 312-9. -
Aversa, G. et al. (1994) A monoclonal antibody (A6) recognizing a unique epitope restricted to CD45RO and RB isoforms of the leukocyte common antigen family identifies functional T cell subsets.
Cell Immunol. 158 (2): 314-28. -
SanSebastian, W. et al. (2013) Adeno-associated virus type 6 is retrogradely transported in the non-human primate brain.
Gene Ther. 20 (12): 1178-83. -
Samaranch, L. et al. (2014) AAV9-mediated expression of a non-self protein in nonhuman primate central nervous system triggers widespread neuroinflammation driven by antigen-presenting cell transduction.
Mol Ther. 22 (2): 329-37.
- UniProt
- P01732
- P10966
- Entrez Gene
- CD8A
- CD8B
- GO Terms
- GO:0005576 extracellular region
- GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
- GO:0005887 integral to plasma membrane
- GO:0015026 coreceptor activity
- GO:0019882 antigen processing and presentation
- GO:0042101 T cell receptor complex
- GO:0042288 MHC class I protein binding
- GO:0050776 regulation of immune response
MCA4609F
153753If you cannot find the batch/lot you are looking for please contact our technical support team for assistance.
Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"
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