CD62P antibody | A05-6A1
Mouse anti Human CD62P:Biotin
- Product Type
- Monoclonal Antibody
- Clone
- A05-6A1
- Isotype
- IgG2b
- Specificity
- CD62P
| Mouse anti Human CD62P antibody, clone A05-6A1, recognizes CD63P, also known as P-Selectin, granule membrane protein 140, LECAM and PADGEM. CD62P is a member of the Selectin family of proteins which are transmembrane Ca2+-dependent lectins that mediate adhesion of leukocytes, platelets and the endothelium during inflammation and immune surveillance (McEver 2015). CD62P is expressed by megakaryocytes and endothelial cells and is stored in membranes of α-granules of platelets and Weibel-Palade bodies of endothelial cells. In humans CD62P can also be secreted as a molecule lacking the transmembrane domain. Increased levels of soluble CD62P in peripheral blood has been documented in a variety of diseases including heart disease, diabetes, hypertension and atrial fibrillation (Polgar et al. 2005). The biotinylated Mouse anti Human CD62P antibody, clone A05-6A1 (MCA6275B) can be used as a detection antibody in a sandwich ELISA with the purified Mouse anti Human CD62P antibody, clone A01-2H1 (MCA6274GA) as the capture antibody. |
- Target Species
- Human
- Product Form
- Purified IgG conjugated to Biotin - liquid
- Preparation
- Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide (NaN3)
1% Bovine Serum Albumin - Immunogen
- HEK293 derived recombinant human full length CD62P (Met1- Ala771)
- Approx. Protein Concentrations
- IgG concentration 0.1 mg/ml
- Fusion Partners
- Cell fusion between immunized BALB/c mouse spleen cells and mouse myeloma SP2/0
- ELISA Matched Pair(s)
-
ELISA Matched Pair-Capture Antibody:
MCA6274GA
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| ELISA |  |
1.0 ug/ml |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
| Description | Product Code | Applications | Pack Size | List Price | Your Price | Quantity | |
|---|---|---|---|---|---|---|---|
| Mouse anti Human CD62P | MCA6274GA | E | 0.1 mg |
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| List Price | Your Price | ||||||
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| Description | Mouse anti Human CD62P | ||||||
- Synonyms
- P--selectin
- UniProt
- P16109
- Entrez Gene
- SELP
- GO Terms
- GO:0001530 lipopolysaccharide binding
- GO:0002576 platelet degranulation
- GO:0005887 integral to plasma membrane
- GO:0005615 extracellular space
- GO:0005624 membrane fraction
- GO:0005625 soluble fraction
- GO:0008201 heparin binding
- GO:0050829 defense response to Gram-negative bacterium
- GO:0009897 external side of plasma membrane
- View More GO Terms
- GO:0010572 positive regulation of platelet activation
- GO:0030168 platelet activation
- GO:0031088 platelet dense granule membrane
- GO:0031092 platelet alpha granule membrane
- GO:0032496 response to lipopolysaccharide
- GO:0033691 sialic acid binding
- GO:0042806 fucose binding
- GO:0043208 glycosphingolipid binding
- GO:0070492 oligosaccharide binding
MCA6275B
100005429
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"
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