Mouse anti Human CCL13 antibody, clone B16-3D8,
recognizes CCL13, a member of the CC family of cytokines. CCL13, also known as MCP-4, is a 98 amino acid (aa) precursor protein which contains a 23 aa hydrophobic signal peptide that is cleaved to the mature form of the protein which is 75aa protein (8kDa). CCL13 is a chemoattractant for various cells including monocytes, T cells, immature dendritic cells and eosinophils (Entiquez & Garcia-Zepeda 2013
). It has also been associated with various inflammatory diseases including asthma, arthritis, atherosclerosis and multiple sclerosis (Procaccini et al. 2015
). CCL13 can bind to several chemokine receptors (CCR1, CCR2 and CCR3) to elicit chemoattractant responses. It is also known to induce degranulation of eosinophils and the secretion of pro-inflammatory cytokines.
This biotinylated Mouse anti Human CCL13 antibody, clone B16-3D8 (MCA6177B) can be used as a detection antibody in a sandwich ELISA with the purified Mouse anti Human CCL13 antibody, clone B06-1G9 (MCA6176GA
) as the capture antibody.
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Applications of CCL13 antibody
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.