CD8 antibody | CT6
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|Mouse anti Guinea Pig CD8 antibody, clone CT6 reacts with guinea pig CD8 present on cytotoxic T-cells. CD8 comprises 2 subunits, alpha and beta and exists as either an alpha/alpha homodimer or an alpha/beta heterodimer. Sequence analysis suggests that guinea pig CD8 is more closely related to human than rat or mouse CD8 (Nagarajan et al. 2004).|
- Target Species
- Guinea Pig
- Product Form
- Purified IgG conjugated to Fluorescein Isothiocyanate Isomer 1 (FITC) - liquid
- Purified IgG prepared by affinity chromatography on Protein A
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
0.09% Sodium Azide 1% Bovine Serum Albumin
- Guinea pig peritoneal T-cells.
- Approx. Protein Concentrations
- IgG concentration 0.1 mg/ml
- Fusion Partners
- Spleen cells from immunised BALB/c mice were fused with cells of the X63.Ag8.653 mouse myeloma cell line.
- Max Ex/Em
Fluorophore Excitation Max (nm) Emission Max (nm) FITC 490 525
- For research purposes only
- 12 months from date of despatch
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended. This product is photosensitive and should be protected from light.
|Application Name||Verified||Min Dilution||Max Dilution|
- Flow Cytometry
- Use 10ul of the suggested working dilution to label 106 cells in 100ul
References for CD8 antibody
Tan, B.T.G. et al. (1985) Production of monoclonal antibodies defining guinea pig T-cell surface markers and a strain 13 Ia-like antigen: the value of immunohistological screening.
Hybridoma 4: 115-124.
Steerenberg, P.A. et al. (1991) Tumour rejection after transfer of line 10 immunity is mediated by two T-cell populations.
Cancer Immunol. Immunother. 34: 103-110.
Steerenberg, P.A. et al. (1990) Tumour infiltrating leucocytes (tils) during progressive tumour growth and BCG - mediated tumour regression.
Virchows Archiv Cell Pathol. 59: 185-194.
Baker, D. et al. (1987) Changes in lymphocyte subsets after treatment with cyclophosphamide and during the development of contact sensitivity in the guinea pig.
Int J Immunopharmacol. 9 (2): 175-83.
Antoniou, A.V. et al. (1986) Immunocytochemical identification and quantitation of mononuclear cells in the meninges during the development of chronic relapsing experimental allergic encephalomyelitis (CREAE) in the guinea pig.
Cell Immunol. 97 (2): 386-96.
Liversidge, J. et al. (1987) EAU in the guinea pig: inhibition of cell-mediated immunity and Ia antigen expression by cyclosporin A.
Clin Exp Immunol. 69 (3): 591-600.
Liversidge, J. & Forrester, J.V. (1988) Experimental autoimmune uveitis (EAU): immunophenotypic analysis of inflammatory cells in chorio retinal lesions.
Curr Eye Res. 7 (12): 1231-41.
Debout, C. et al. (1991) The Kurloff cell in estrogenized guinea pigs as a CT7+ 8BE6- CT6- MR-1- CT10- IgM- lymphocyte with natural killer activity.
Nat Immun Cell Growth Regul. 10 (6): 327-35.
View The Latest Product References
Shang S et al. (2011) Activities of TMC207, rifampin, and pyrazinamide against Mycobacterium tuberculosis infection in guinea pigs.
Antimicrob Agents Chemother. 55 (1): 124-31.
Lacy HM et al. (2011) Essential role for neutrophils in pathogenesis and adaptive immunity in Chlamydia caviae ocular infections.
Infect Immun. 79 (5): 1889-97.
Komori, T. et al. (2011) A Microbial Glycolipid Functions as a New Class of Target Antigen for Delayed-type Hypersensitivity.
J Biol Chem. 286: 16800-6.
Hiromatsu, K. et al. (2002) Induction of CD1-restricted immune responses in guinea pigs by immunization with mycobacterial lipid antigens.
J Immunol. 169: 330-9.
Kramp, J.C. et al. (2011) The in vivo immunomodulatory effect of recombinant tumour necrosis factor-alpha in guinea pigs vaccinated with Mycobacterium bovis bacille Calmette-Guérin.
Clin Exp Immunol. 165: 110-20.
Mishra, N.C. et al. (2010) Sulfur mustard induces immune sensitization in hairless guinea pigs.
Int Immunopharmacol. 10: 193-9.
Schleiss, M.R. et al. (2007) Preconceptual administration of an alphavirus replicon UL83 (pp65 homolog) vaccine induces humoral and cellular immunity and improves pregnancy outcome in the guinea pig model of congenital cytomegalovirus infection.
J Infect Dis. 195: 789-98.
Turner, O.C. et al. (2003) Immunopathogenesis of pulmonary granulomas in the guinea pig after infection with Mycobacterium tuberculosis.
Infect Immun. 71: 864-71.
Wang, Y. et al. (2010) Local host response to chlamydial urethral infection in male guinea pigs.
Infect Immun. 78: 1670-81.
Yang, H. et al. (2011) Three protein cocktails mediate delayed-type hypersensitivity responses indistinguishable from that elicited by purified protein derivative in the guinea pig model of Mycobacterium tuberculosis infection.
Infect Immun. 79: 716-23.
Baldwin SL et al. (2012) The importance of adjuvant formulation in the development of a tuberculosis vaccine.
J Immunol. 188 (5): 2189-97.
Obregón-Henao, A. Shang, s. Shanley, C.A. Basaraba, R.J. Caraway, M.L. Duncan, C.G. Ordway, D.J. Orme, I.M. (2013) Cortisone-Forced Reactivation of Weakly Acid Fast Positive Mycobacterium Tuberculosis in Guinea Pigs Previously Treated With Chemotherapy
Mycobacterial Diseases. 2: 116.
Xia, J. et al. (2014) Virus-specific immune memory at peripheral sites of herpes simplex virus type 2 (HSV-2) infection in guinea pigs.
PLoS One. 9 (12): e114652.
Jeevan A et al. (2013) Guinea pig skin, a model for epidermal cellular and molecular changes induced by UVR in vivo and in vitro: effects on Mycobacterium bovis Bacillus Calmette-Guérin vaccination.
Photochem Photobiol. 89 (1): 189-98.
Gupta A et al. (2012) Protective efficacy of Mycobacterium indicus pranii against tuberculosis and underlying local lung immune responses in guinea pig model.
Vaccine. 30 (43): 6198-209.
Gupta, A. et al. (2012) Efficacy of Mycobacterium indicus pranii immunotherapy as an adjunct to chemotherapy for tuberculosis and underlying immune responses in the lung.
PLoS One. 7 (7): e39215.
Wu, W.H. et al. (2012) Immune status and the development of Listeria monocytogenes infection in aged and young guinea pigs.
Clin Invest Med. 35 (5): E309.
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