Biomarker Expression Patterns in Bovine, Canine, Porcine and AvianDownload now
Several bovine and ovine antibodies against cytokines have been tested and shown to be suitable for caprine research.
Our antibodies against bovine IFN gamma and bovine IL-4 are well characterized, and are shown to cross-react with goat. Our anti-ovine IL-1 beta monoclonal and anti-ovine IL-8 polyclonal antibodies are also suitable for use with caprine samples.
Measurement of interferon gamma (IFN-γ) and interleukin-4 (IL-4) plays an important role in evaluating the immune status of animals. IFN-γ is a secreted, pro-inflammatory cytokine, produced by lymphocytes in response to activation by specific antigens or mitogens. IL-4 plays a critical role in influencing antigen-activated naïve CD4+ T cells to develop into Th2 cells. Th2 cells are associated with specific immune responses, including those against large extracellular parasites.
Our anti-bovine IL-4 antibodies, clones CC313 and CC314, are suitable for use in sandwich ELISA. A publication in Research in Veterinary Science cites the use of these antibodies to measure soluble IL-4 in caprine PBMC culture supernatants.