We offer a comprehensive range of monoclonal and polyclonal antibodies to key coagulation and hematology related biomarkers, for research purposes as well as diagnostic assay development.
Human von Willebrand factor (vWF) is a large glycoprotein involved in blood coagulation. It carries and stabilizes the procoagulant protein Factor VIII by binding to it and protecting it from cleavage and delivers it to sites of vascular injury. The deficiency or structural defect of vWF and FVIII leads to the common inherited bleeding disorders, von Willenbrand’s disease (VWD) and hemophilia A (HA).
Transferrin is the primary blood iron transport. Measurement of blood transferrin levels can be used as an indicator for blood iron-carrying capacity and abnormalities of iron metabolism such as anaemia, iron overload and haemochromatosis.
Fibrinogen, synthesised in the liver, is another plasma glycoprotein that plays an important role in the coagulation cascade. These processes involve the conversion of fibrinogen to fibrin, and their interaction to various proteins and cells. A fibrinogen activity test is often performed to investigate a possible bleeding disorder. It is sometimes used to help evaluate the risk of developing a cardiovascular disease, together with other cardiac risk markers such as C-reactive protein (CRP).