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Baby Rabbit Complement

Product Code Applications Pack Size List Price Your Price Qty
C12CA.1
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SDS Safety Datasheet SDS
FN * IY 1 ml loader
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C12CA
Datasheet Datasheet Datasheet
SDS Safety Datasheet SDS
FN * IY 2 ml loader
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Baby rabbit complement serum preparation is intended for use as a source of rabbit complement for cytotoxicity assays.

Product Form
Baby rabbit serum - lyophilized
Reconstitution
C12CA.1: Reconstitute with 1.0 ml ice cold distilled water
C12CA: Reconstitute with 2ml ice cold distilled water
Preservative Stabilisers
None present
Regulatory
For research purposes only
Guarantee
Guaranteed until date of expiry. Please see product label.

Prior to reconstitution store at +4oC. Following reconstitution store at +4oC for 1 hour or aliquot and store at -70oC for longer.

This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the product. Should this product contain a precipitate we recommend microcentrifugation before use.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Functional Assays 1
Immunoassay
  1. 1 This product is not sold as sterile but can be sterilized by filtration if necessary. It is preferable to dilute the complement to a final working concentration before filtration in order to minimize loss of volume.
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
Instructions For Use
Use within one hour of reconstitution, keeping on ice throughout.

References for Baby Rabbit Complement

  1. De clercq, L. et al. (1997) An anti-adipocyte monoclonal antibody is cytotoxic to porcine preadipocytes in vitro and depresses the development of pig adipose tissue.
    J Anim Sci. 75 (7): 1791-7.
  2. Anderson, L.D. Jr et al. (1999) Enhancement of graft-versus-tumor activity and graft-versus-host disease by pretransplant immunization of allogeneic bone marrow donors with a recipient-derived tumor cell vaccine.
    Cancer Res. 59 (7): 1525-30.
  3. Lidington, E.A. et al. (2000) Induction of decay-accelerating factor by thrombin through a protease-activated receptor 1 and protein kinase C-dependent pathway protects vascular endothelial cells from complement-mediated injury.
    Blood. 96 (8): 2784-92.
  4. Mason, J.C. et al. (2002) bFGF and VEGF synergistically enhance endothelial cytoprotection via decay-accelerating factor induction.
    Am J Physiol Cell Physiol. 282: C578-87.
  5. Mason, J.C. et al. (2002) Statin-induced expression of decay-accelerating factor protects vascular endothelium against complement-mediated injury.
    Circ Res. 91 (8): 696-703.
  6. Li, S.H. et al. (2004) C-reactive protein upregulates complement-inhibitory factors in endothelial cells.
    Circulation. 109: 833-6.
  7. Newcombe, J. et al. (2004) Infection with an avirulent phoP mutant of Neisseria meningitidis confers broad cross-reactive immunity.
    Infect Immun. 72: 338-44.
  8. Sancho, D. et al. (2006) CD69 targeting differentially affects the course of collagen-induced arthritis.
    J Leukoc Biol. 80: 1233-41.
  9. View The Latest Product References
  10. Hyams, C. et al. (2010) Streptococcus pneumoniae resistance to complement-mediated immunity is dependent on the capsular serotype.
    Infect Immun. 78: 716-25.
  11. Hung, M.C. et al. (2011) The Neisseria meningitidis Macrophage Infectivity Potentiator Protein Induces Cross-Strain Serum Bactericidal Activity and Is a Potential Serogroup B Vaccine Candidate.
    Infect Immun. 79: 3784-91.
  12. Lee, S.J. et al. (2012) Identification of a common immune signature in murine and human systemic Salmonellosis.
    Proc Natl Acad Sci U S A. 109 (13): 4998-5003.
  13. Hung MC et al. (2013) The adhesin complex protein (ACP) of Neisseria meningitidis is a new adhesin with vaccine potential.
    MBio. 4 (2): pii: e00041-13.
  14. Goh, Y.S. & MacLennan, C.A. (2013) Invasive African nontyphoidal Salmonella requires high levels of complement for cell-free antibody-dependent killing.
    J Immunol Methods. 387 (1-2): 121-9.
  15. Goh YS et al. (2016) Bactericidal Immunity to Salmonella in Africans and Mechanisms Causing Its Failure in HIV Infection.
    PLoS Negl Trop Dis. 10 (4): e0004604.
  16. Humbert MV et al. (2016) Vaccine Potential and Diversity of the Putative Cell Binding Factor (CBF, NMB0345/NEIS1825) Protein of Neisseria meningitidis.
    PLoS One. 11 (8): e0160403.
  17. Dierckx de Casterlé I et al. (2018) Reduction of myeloid-derived suppressor cells reinforces the anti-solid tumor effect of recipient leukocyte infusion in murine neuroblastoma-bearing allogeneic bone marrow chimeras.
    Cancer Immunol Immunother. 67 (4): 589-603.
  18. Valton, J. et al. (2018) A Versatile Safeguard for Chimeric Antigen Receptor T-Cell Immunotherapies.
    Sci Rep. 8 (1): 8972.
  19. Dierckx de Casterlé, I. et al. (2018) Reduction of myeloid-derived suppressor cells reinforces the anti-solid tumor effect of recipient leukocyte infusion in murine neuroblastoma-bearing allogeneic bone marrow chimeras.
    Cancer Immunol Immunother. 67 (4): 589-603.
  20. Nganje, C.N. et al. (2019) PepN is a non-essential, cell wall-localized protein that contributes to neutrophil elastase-mediated killing of Streptococcus pneumoniae.
    PLoS One. 14 (2): e0211632.
  21. Cuesta-Mateos, C. et al. (2020) CCR7 as a novel therapeutic target in t-cell PROLYMPHOCYTIC leukemia
    Biomarker Research.8, 54.
  22. Mosti, L. et al. (2021) Targeted multi-epitope switching enables straightforward positive/negative selection of CAR T cells.
    Gene Ther. 28 (9): 602-12.
  23. Olivera-Ardid, S. et al. (2023) Removal of natural anti-αGal antibodies elicits protective immunity against Gram-negative bacterial infections.
    Front Immunol. 14: 1232924.

Functional Assays

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