Measles Virus
Inactivated Measles virus, Edmonston strain (PIP013) used as a target antigen for the evaluation of patient seropositivity by ELISA.
Image caption:
Simple dot plot representation of anti-measles IgG seropositivity ratios. During result computation, no discrimination was made between immune responses elicited by vaccination and those triggered by natural infection, including subsequent seroconversion. The analysis relied on quantitative data obtained through immunoassays (ELISAs), which were then translated into qualitative outcomes (positive or negative). Seropositivity = number of positive samples per age group/total number of samples per age group × 100. Dots are connected solely to facilitate visual tracking of consistent trends between countries, serving the purpose of facilitating easy interpretation based on direct observation. (a) Anti-measles IgG seropositivity ratios;
From: Szinger, D.; Berki, T.; Drenjančević, I.; Samardzic, S.; Zelić, M.; Sikora, M.; Požgain, A.; Markovics, Á.; Farkas, N.; Németh, P.; et al.
Raising Epidemiological Awareness: Assessment of Measles/MMR Susceptibility in Highly Vaccinated Clusters within the Hungarian and Croatian Population—A Sero-Surveillance Analysis.
Vaccines 2024, 12, 486.
doi: 10.3390/vaccines12050486
This image is from an open access article distributed under terms of a Creative Commons Attribution License.
Inactivated Measles virus, Edmonston strain (PIP013) used as a target antigen for the evaluation of patient seropositivity by ELISA.
Image caption:
Assessing nonoverlapping confidence intervals for age group comparison. The Clopper–Pearson exact binomial confidence interval was used as a statistical method in order to calculate the confidence interval for a proportion regarding our binomial data (positive or negative seropositivity outcomes). The absence of overlap in confidence intervals (CI 95%) was interpreted as indicative of a statistically significant difference between the respective age groups. For detailed analysis, structured in a clear, table-based design, highlighting only the nonoverlapping confidence intervals between age groups.
From: Szinger, D.; Berki, T.; Drenjančević, I.; Samardzic, S.; Zelić, M.; Sikora, M.; Požgain, A.; Markovics, Á.; Farkas, N.; Németh, P.; et al.
Raising Epidemiological Awareness: Assessment of Measles/MMR Susceptibility in Highly Vaccinated Clusters within the Hungarian and Croatian Population—A Sero-Surveillance Analysis.
Vaccines 2024, 12, 486.
doi: 10.3390/vaccines12050486
This image is from an open access article distributed under terms of a Creative Commons Attribution License.
Native Measles Virus
- Product Type
- Antigen
- Specificity
- Measles Virus
Antibody Quality and Performance Guarantee
| Native Measles Virus preparation contains a high concentration of virus and viral components. The preparation also contains some cellular material suspended in tissue culture medium. The Measles virus is a highly contagious single-stranded RNA virus that is mostly spread via the respiratory system. It may be passed via aerosol droplets from coughs or through contact with infected bodily fluids. It causes measles, a disease characterised by fever, cough, runny nose, red eyes and a rash. Most patients with uncomplicated measles will recover without antiviral treatment, however, some patients may develop diarrhoea, corneal ulceration, pneumonia or encephalitis. Complications are more likely in adults. In developed countries, most children are immunised against measles by the age of 18 months, as part of the three-part MMR (measles, mumps and rubella) vaccine. |
- Target Species
- Viral
- Product Form
- Inactivated Measles virus - liquid
- Preparation
- Measles virus, Edmonston strain, cultured in Vero cells. Optimally infected cells are disrupted in culture fluids. The suspension is clarified and concentrated by crossflow ultrafiltration. The antigen preparation is inactivated using gamma radiation, which primarily damages viral genetic material.
- Buffer Solution
- Minimum Essential Medium
- Preservative Stabilisers
- None present
- Activity
- Antigenic activity is 104% of internal reference standard.
- Approx. Protein Concentrations
- Current, batch-specific concentration 2.3 mg/ml
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
Store at -70oC.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the protein.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the protein.
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| ELISA |  |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
- Instructions For Use
-
PIP013
PIP013 should be sonicated immediately before use to ensure the preparation is uniform. The product may be used in a variety of immunoassay formats or may be further purified to meet the requirements of a particular assay format.
References for Measles Virus
-
Bhoj, V.G. et al. (2016) Persistence of long-lived plasma cells and humoral immunity in individuals responding to CD19-directed CAR T-cell therapy.
Blood. 128 (3): 360-70. -
Böröcz, K. et al. (2022) Dynamic Features of Herd Immunity: Similarities in Age-Specific Anti-Measles Seroprevalence Data between Two Countries of Different Epidemiological History.
J Clin Med. 11(4):1145. -
Szinger, D. et al. (2024) Raising Epidemiological Awareness: Assessment of Measles/MMR Susceptibility in Highly Vaccinated Clusters within the Hungarian and Croatian Population—A Sero-Surveillance Analysis
Vaccines. 12 (5): 486.
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