Campus Neuried, Anna-Sigmund-Str. 5, 82061 Neuried, Germany
Get in touch with us to discuss your project and discover how the Pioneer Antibody Discovery Platform can help identify your new therapeutic candidates.
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The New
Pioneer Antibody
Discovery Platform
Step into the Future
of Therapeutic Antibody Discovery
The new Pioneer Antibody Discovery Platform features a state-of-the-art phage display human antibody library for biotherapeutic antibody discovery. The highly-curated library is a 1000 times bigger than the normal human immune repertoire and is designed to offer maximum functional diversity and affinity with excellent developability.
The Pioneer Antibody Discovery Platform delivers a greater selection of candidates with diverse binding activity, and hence a significantly improved opportunity to identify a superior therapeutic antibody.
Our Technology
Diversity, Affinity, and Developability
With decades of experience in custom antibody generation, Bio-Rad has now developed an entirely new phage display library called Pioneer. Harnessing SpyTag technology it has been engineered with a proprietary display method, SpyDisplay, to enable the rapid discovery of therapeutic antibody candidates.
The Pioneer Antibody Discovery Platform is an exceptionally large functional, phage display Fab antibody library, containing 2.25 x 1011 unique antibodies, thereby delivering a high and diverse number of unique hits.
The large size of the library delivers diverse lead candidates with sub-nanomolar affinities possible from initial panning’s. Affinity maturation can be used to further optimize promising therapeutic candidates.
The Pioneer Antibody Discovery Platform has been engineered focusing on developability — post-translational modifications and other sequence liabilities have been minimized to achieve best-in-class developable candidates for your target of interest.
The large size of the library delivers diverse lead candidates with sub-nanomolar affinities possible from initial panning’s. Affinity maturation can be used to further optimize promising therapeutic candidates.
The Pioneer Antibody Discovery Platform has been engineered focusing on developability — post-translational modifications and other sequence liabilities have been minimized to achieve best-in-class developable candidates for your target of interest.
SpyDisplay Technology
Our innovative SpyDisplay technology simplifies and accelerates candidate selection. SpyDisplay utilizes a single vector for both selections during phage display and expression of clones after screening thereby improving workflow efficiency with a less error prone process.
An exceptionally large, functional phage display Fab antibody library
Key Features of the Pioneer Antibody Discovery Platform
Fully synthetic, fully human Fab antibody library specifically designed to minimize nonproductive cloning artefacts — 96% of sequences encode functional light and heavy chains.
- New Antibody library with exceptional size and broad functional diversity
- Proprietary SpyDisplay technology for accelerated candidate selection
- Prototyping of therapeutic candidates in a multitude of formats with TrailBlazer technology
- Ownership of candidates
- World-class specialists and scientists offering a tailored service to your needs
The Pioneer Antibody Discovery Services will deliver:
Evaluation material in rapid prototyping format (based on Bio-Rad‘s proprietary TrailBlazer platform) specific to the clients requirements.
The final antibodies are fully mammalian expressed IgGs, functionally characterized with a complete data package and sequence.
Exclusivity and ownership of sequences of antibody deliverables.
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