ATIC Antibody | F38 P7 H9

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Staining of paraffin embedded human colon carcinoma with Mouse anti Human ATIC (MCA2621)

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  • Product Type
    Monoclonal Antibody
  • Clone
    F38 P7 H9
  • Isotype
    IgG1
1 Formats Available
    Product CodeApplicationsDatasheetMSDSPack SizeList PriceQuantity
    MCA2621GAP, WBdatasheet pdfdatasheet pdf0.1 mg
    MCA2621GA
    Summary
    Secondary Antibodies
    Negative Isotype Controls
    Useful Reagents
    Positive Controls
    Histology Controls
    More Images
    References
    Reviews
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    • Mouse anti ATIC antibody, clone F38 P7 H9 specifically recognizes ATIC,a ribonucleotide transformylase (AICAR transformylase) and member of the purH family, which helps catalyze the final steps of the purine biosynthesis pathway.

      ATIC has been identified as an activator of AMP-activated protein kinase (AMPK), a known regulator of energy homeostasis, inhibitor of cell proliferation and inducer of apoptosis in cancerous cells of various origins, making ATIC a potential therapeutic agent for cancer. The anti-inflammatory and neuroprotective functions of ATIC, also have implications for its use in the treatment of Alzheimer's disease.
    • Intended Use
    • Target Species
      Synthetic Peptide
    • Species Cross-Reactivity
      Target SpeciesCross Reactivity
      Ratyes
      Mouseyes
      Drosophilayes
      Xenopusyes
      Humanyes
      N.B. Antibody reactivity and working conditions may vary between species.
    • Product Form
      Purified IgG - liquid
    • Reconstitution
    • Preparation
      Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
    • Preservative Stabilisers
      0.09%Sodium Azide (NaN3)
    • Immunogen
      Ovalbumin-conuugated synthetic peptide AHTNLRLFHH
    • Purity
    • Approx. Protein Concentrations
      IgG concentration 1.0mg/ml
    • Reagents In The Kit
    • Preparing The Antibody
    • Test Principle
    • Buffer Solution
      Phosphate buffered saline
    • Storage
      Store at +4oC or at -20oC if preferred.
      Storage in frost-free freezers is not recommended.
      This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
    • Shelf Life
      18 months from date of despatch.
    • GO Terms
      protein homodimerization activity
      IMP cyclohydrolase activity
      phosphoribosylaminoimidazolecarboxamide formyltransferase activity
      cytosol
      purine base metabolic process
      IMP biosynthetic process
    • UniProt
    • Entrez Gene
    • Acknowledgements
    • Regulatory
      For research purposes only
    • This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.

    • Application NameYesNoMin DilutionMax Dilution
      Immunohistology - Paraffin1/501/500
      Western Blotting

    • Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
    • Technical Advice
    • Recommended Protocol
    • ELISA
    • Immunohistology
      This product does not require antigen retrieval using heat treatment prior to staining of paraffin sections.
    • Histology Positive Control Tissue
      Colon carcinoma
    • Immunofluorescence
    • Western Blotting
      MCA2621GA detects a band of approximately 65.0kDa in HT29 and CACO-2 cell lysates.
    • Instructions For Use

    Additional ATIC Antibody Formats

    Formats Clone Applications Sizes available
    ATIC Antibody : Purified F38 P7 H9 P, WB 0.1 mg
    • Copyright © 2016 Bio-Rad

    Recommended Secondary Antibody

      Recommended Negative Isotype Control

        Useful Reagents

          Recommended Positive Controls

            Histology Controls

              Colon carcinoma

              Further Reading

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