Nmdar NR2B antibody

Prior to reconstitution store at +4^oC.
After reconstitution store at -20^oC.
Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.

Application Name	Verified	Min Dilution	Max Dilution
Immunohistology - Frozen		1/1000	1/2000
Immunoprecipitation
Western Blotting

Technical Advice

3 µl of antibody will quantitatively immunoprecipitate all NMDAR2B in 200 µg of rat brain. Optimal working dilutions must be determined by the end user.

Histology Positive Control Tissue

Hippocampus.

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References for Nmdar NR2B antibody

1. Grosshans, D.R. and Browning, M.D. (2001) Protein kinase C activation induces tyrosine phosphorylation of the NR2A and NR2B subunits of the NMDA receptor.
   J Neurochem. 76: 737-44.
2. Asaka, Y. et al. (2006) Hippocampal synaptic plasticity is impaired in the Mecp2-null mouse model of Rett syndrome.
   Neurobiol Dis. 21: 217-27.
3. Maliszewska-Cyna, E. et al. (2010) Diminished prevalence but preserved synaptic distribution of N-methyl-D-aspartate receptor subunits in the methyl CpG binding protein 2(MeCP2)-null mouse brain.
   Neuroscience. 168: 624-32

RRID

AB_620698

UniProt

Q00960

Entrez Gene

Grin2b

GO Terms

GO:0001508 regulation of action potential

GO:0001975 response to amphetamine

GO:0050839 cell adhesion molecule binding

GO:0004972 N-methyl-D-aspartate selective glutamate receptor activity

GO:0005234 extracellular-glutamate-gated ion channel activity

GO:0007616 long-term memory

GO:0008013 beta-catenin binding

GO:0008144 drug binding

GO:0008270 zinc ion binding

View More GO Terms

GO:0008306 associative learning

GO:0051707 response to other organism

GO:0009743 response to carbohydrate stimulus

GO:0010350 cellular response to magnesium starvation

GO:0010942 positive regulation of cell death

GO:0014049 positive regulation of glutamate secretion

GO:0014069 postsynaptic density

GO:0016600 flotillin complex

GO:0017146 N-methyl-D-aspartate selective glutamate receptor complex

GO:0021766 hippocampus development

GO:0021987 cerebral cortex development

GO:0030018 Z disc

GO:0030054 cell junction

GO:0030288 outer membrane-bounded periplasmic space

GO:0031749 D2 dopamine receptor binding

GO:0032026 response to magnesium ion

GO:0034097 response to cytokine stimulus

GO:0035235 ionotropic glutamate receptor signaling pathway

GO:0035255 ionotropic glutamate receptor binding

GO:0042165 neurotransmitter binding

GO:0042220 response to cocaine

GO:0042734 presynaptic membrane

GO:0043083 synaptic cleft

GO:0043113 receptor clustering

GO:0043195 terminal button

GO:0043197 dendritic spine

GO:0043408 regulation of MAPKKK cascade

GO:0045211 postsynaptic membrane

GO:0045471 response to ethanol

GO:0046982 protein heterodimerization activity

GO:0048169 regulation of long-term neuronal synaptic plasticity

GO:0048511 rhythmic process

GO:0050806 positive regulation of synaptic transmission

GO:0051592 response to calcium ion

GO:0051597 response to methylmercury

GO:0051602 response to electrical stimulus

GO:0060416 response to growth hormone stimulus

GO:0060992 response to fungicide

GO:0071230 cellular response to amino acid stimulus

GO:0071287 cellular response to manganese ion

GO:0071359 cellular response to dsRNA

GO:0071363 cellular response to growth factor stimulus

GO:0071396 cellular response to lipid

GO:0071407 cellular response to organic cyclic compound

GO:0071445 cellular response to protein stimulus

6870-1109

171031 171110

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