Low Density Lipoprotein

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Native Human Low Density Lipoprotein (Acetylated)

Product Type
Purified Protein
Product CodeApplicationsDatasheetMSDSPack SizeList PriceQuantity
5685-3404 E 2 mg
Acetylated Low Density Lipoprotein (AcLDL) is taken up by cells via scavenger receptors and has been used as a mechanism of targeted drug delivery and in combination with saporin for the depletion of specific cell types. AcLDL behaves like oxidised LDL, both of which are degraded within lysosomes.

Product Details

Target Species
Human
Product Form
Purified acetylated LDL from human serum - liquid
Preparation
Purified to homogeneity via ultracentrifugation and acetylated with excess acetic anhydride.
Buffer Solution
TRIS buffered saline
Preservative Stabilisers
0.3 mM EDTA
Activity
Each lot has been evaluated for receptor binding to murine peritoneal macrophages in conjunction with [I-125] Ac-LDL or Dil-AcLDL
Approx. Protein Concentrations
2.0 mg/ml

Storage Information

Storage
Store at +4oC. DO NOT FREEZE.
This product should be stored undiluted. After prolonged storage some precipitate may be observed. This is normal for this product and you should centrifuge at 500 g for ten minutes to clarify. This product has been aseptically packaged and membrane filtered. Handle aseptically.
Shelf Life
Please see label for expiry date.

More Information

Regulatory
For research purposes only

Applications of Low Density Lipoprotein

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
ELISA
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using the appropriate negative/positive controls.

Product Specific References

References for Low Density Lipoprotein

  1. Limmon, G.V. et al. (2008) Scavenger receptor class-A is a novel cell surface receptor for double-stranded RNA.
    FASEB J. 22: 159-67.
  2. Spitsin, S. et al. (2017) Antiinflammatory effects of aprepitant coadministration with cART regimen containing ritonavir in HIV-infected adults.
    JCI Insight. 2 (19)Oct 05 [Epub ahead of print].