IL-22

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Recombinant Human Interleukin-22

Product Type: Recombinant Protein
Specificity: IL-22

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Interleukin-22 (IL-22) is a regulatory cytokine and member of the IL-10 family, secreted by activated T cells, which signals through a class II cytokine receptor system consisting of IL-22R and IL-10R-beta/CRF2-4.

IL-22 has been shown to act as an inhibitor of the production of IL-4 by Th2 cells, up-regulate the production of acute phase reactants in the pancreas and liver, and to be up-regulated in intestinal inflammation associated with Crohn’s disease.

Target Species: Human
Product Form: Purified recombinant protein - lyophilized
Reconstitution: Reconstitute with 20ul distilled water. Care should be taken during reconstitution as the protein may appear as a film at the bottom of the vial. Bio-Rad recommend that the vial is gently mixed after reconstitution.
Preparation: Purified recombinant IL-22 expressed in E.coli
Source: E.coli
Preservative Stabilisers: None present
Carrier Free: Yes
Activity: Determined by its ability to activate STAT following receptor ligand interaction
Purity: >98% by SDS PAGE and HPLC analysis
Approx. Protein Concentrations: 0.5 mg/ml after reconstitution
Protein Molecular Weight: 33.6 kDa (146 amino acid homodimer)
Endotoxin Level: < 1.0 EU/ug
Regulatory: For research purposes only
Guarantee: Guaranteed for 3 months from the date of reconstitution or until the date of expiry, whichever comes first. Please see label for expiry date.

Prior to reconstitution store at -20^oC.
After reconstitution store at -20^oC.
Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.

Application Name	Verified	Min Dilution	Max Dilution
Functional Assays

Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.

Synonyms: IL-TIF
UniProt: Q9GZX6
Entrez Gene: IL22
GO Terms: GO:0006953 acute-phase response; GO:0005125 cytokine activity; GO:0005615 extracellular space; GO:0007267 cell-cell signaling; GO:0045518 interleukin-22 receptor binding