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IFN Beta 1A

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Recombinant Human Interferon Beta 1 Alpha

Product Type
Recombinant Protein
Specificity
IFN Beta 1A

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OBT1546A
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Recombinant human interferon beta 1a is a CHO cell derived recombinant protein corresponding to single, glycosylated polypeptide chain containing 166 amino acid residues. Interferon beta 1a is a 22 kDa cytokine and member of the type 1 interferon family.

Interferons exhibit anti-viral and anti proliferative effects and also influence the immune response. Effects on the immune system mediated by interferons may be mediated by increased expression of major histocompatability complex (MHC) antigens. Interferon beta a has been shown to exhibit therapeutic efficacy against viral infections, different types of cancer and multiple sclerosis (Borden et al. 2007).

Target Species
Human
Product Form
Recombinant protein - lyophilized
Reconstitution
Reconstitute with 50ul of distilled water
Care should be taken during reconstitution as the protein may appear as a film at the bottom of the vial. Bio-Rad recommend that the vial is gently mixed after reconstitution.
Source
CHO cells
Preservative Stabilisers
0.34M Mannitol
0.9% human serum albumin
Activity
270 x 106 IU/mg, as determined in a viral resistance assay
Purity
>98.0% as determined by HPLC and SDS-PAGE.
Approx. Protein Concentrations
Total protein concentration 0.1 mg/ml after reconstitution
Regulatory
For research purposes only
Guarantee
12 months from date of despatch

Prior to reconstitution store at +4oC.
After reconstitution store at -20oC.
Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the protein. Should this product contain a precipitate we recommend microcentrifugation before use.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Functional Assays
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.

References for IFN Beta 1A

  1. Smith, M.C. et al. (2013) hTERT extends the life of human fibroblasts without compromising type I interferon signaling.
    PLoS One. 8 (3): e58233.

Further Reading

  1. Borden, E.C. et al. (2007) Interferons at age 50: past, current and future impact on biomedicine
    Nat Rev Drug Discov. 6: 975-90

Synonyms
Interferon Beta
UniProt
P01574
Entrez Gene
IFNB1
GO Terms
GO:0003714 transcription corepressor activity
GO:0007596 blood coagulation
GO:0005125 cytokine activity
GO:0005132 interferon-alpha/beta receptor binding
GO:0005615 extracellular space
GO:0006917 induction of apoptosis
GO:0006919 activation of caspase activity
GO:0008285 negative regulation of cell proliferation
GO:0010552 positive regulation of gene-specific transcription from RNA polymerase II promoter
GO:0030101 natural killer cell activation
GO:0032897 negative regulation of viral transcription
GO:0042100 B cell proliferation
GO:0045071 negative regulation of viral genome replication
GO:0045089 positive regulation of innate immune response
GO:0045343 regulation of MHC class I biosynthetic process
GO:0046597 negative regulation of virion penetration into host cell
GO:0051607 defense response to virus
GO:0060337 type I interferon-mediated signaling pathway
GO:0060338 regulation of type I interferon-mediated signaling pathway
GO:0071360 cellular response to exogenous dsRNA

OBT1546A

148368 153982 163784

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