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Annexin II

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Recombinant Human Annexin II

Product Type
Recombinant Protein
Specificity
Annexin II

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PHP227
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Annexin II (ANXA2), otherwise known as Lipocortin II, is a pleiotropic calcium-dependent phospholipid-binding protein and member of the annexin family, which acts as an autocrine factor, enhancing the formation of osteoclasts and resorption of bone, and is implicated in both exocytosis and endocytosis. ANXA2 is a substrate for both tyrosine and serine/threonine kinases, and is phosphorylated following growth factor stimulation and cellular activation by viral transformation.

Target Species
Human
Product Form
Purified recombinant protein - liquid
Preparation
Purified recombinant 6xHis-tagged ANXA2 expressed in E.coli
Source
E.coli
Buffer Solution
Phosphate buffered saline.
Preservative Stabilisers
None present
Approx. Protein Concentrations
0.1 mg/ml
Protein Molecular Weight
41.3 kDa (361 amino acid residues with tag)
Endotoxin Level
<0.1 ng/ug
Regulatory
For research purposes only
Guarantee
12 months from date of despatch
Acknowledgements
His-tag is a registered trademark of EMD Biosciences.

Store at -70oC.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
ELISA
Western Blotting 1 5ug/lane
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.

References for Annexin II

  1. Lee, J. et al. (2021) Data on G-quadruplex topology, and binding ability of G-quadruplex forming sequences found in the promoter region of biomarker proteins and those relations to the presence of nuclear localization signal in the proteins.
    Data Brief. 36: 107028.

Circular dichroism

Gel Super Shift Assays

UniProt
P07355
Entrez Gene
ANXA2
GO Terms
GO:0001501 skeletal system development
GO:0005509 calcium ion binding
GO:0004859 phospholipase inhibitor activity
GO:0005544 calcium-dependent phospholipid binding
GO:0005604 basement membrane
GO:0005625 soluble fraction
GO:0008092 cytoskeletal protein binding
GO:0030496 midbody
GO:0031340 positive regulation of vesicle fusion
GO:0042470 melanosome

PHP227

090413

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