Alpha 2 Macroglobulin

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Native Human Alpha 2 Macroglobulin

Product Type
Purified Protein
Product CodeApplicationsDatasheetMSDSPack SizeList PriceQuantity
5850-2004 E 1 mg
Alpha 2 macroglobulin, also known as α2-macroglobulin and abbreviated as α2M and A2M, is a tetrameric glycoprotein produced in the liver and found in blood. It is involved in proteinase inhibition via a unique "trapping" mechanism.

Product Details

Target Species
Product Form
Purified alpha 2 macroglobulin from human serum - liquid
Buffer Solution
TRIS buffered saline
Preservative Stabilisers
0.1M Sucrose
>96% by SDS PAGE
Approx. Protein Concentrations
Total protein concentration 1.0 mg/ml
Protein Molecular Weight
725 kDa

Storage Information

Store at -20oC only.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the protein.
Shelf Life
12 months from date of despatch

More Information

P01023 Related reagents
Entrez Gene
A2M Related reagents
GO Terms
GO:0001869 negative regulation of complement activation, lectin pathway
GO:0002576 platelet degranulation
GO:0005829 cytosol
GO:0004867 serine-type endopeptidase inhibitor activity
GO:0005096 GTPase activator activity
GO:0005615 extracellular space
GO:0007264 small GTPase mediated signal transduction
GO:0007597 blood coagulation, intrinsic pathway
GO:0019899 enzyme binding
GO:0019959 interleukin-8 binding
GO:0019966 interleukin-1 binding
GO:0030168 platelet activation
GO:0031093 platelet alpha granule lumen
GO:0043120 tumor necrosis factor binding
GO:0051056 regulation of small GTPase mediated signal transduction
For research purposes only

Applications of Alpha 2 Macroglobulin

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.

Product Specific References

References for Alpha 2 Macroglobulin

  1. Barret, A. J. et al. (1981) Alpha 2-macroglobulin.
    Methods Enzymol 80: 737-754.