MBP

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Native Bovine MBP

Product Type
Purified Protein
Product CodeApplicationsDatasheetMSDSPack SizeList PriceQuantity
6420-0100 E 5 mg
Myelin Basic Protein is one of the most abundant proteins of the myelin membrane in the central nervous system. It plays a role in nerve myelination. MBP may play a role in demyelinating diseases including Multiple Sclerosis.

Product Details

Target Species
Bovine
Product Form
Purified protein from bovine brain - lyophilised
Reconstitution
Reconstitute with 1ml of 10mM HCl.
Buffer Solution
Essentially salt free
Preservative Stabilisers
None Present.
Purity
SDS PAGE: >90%

Storage Information

Storage
Prior to reconstitution store at +4oC.
After reconstitution store at -20oC.
Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the protein. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life
6 months from date of despatch.

More Information

UniProt
P02687 Related reagents
Entrez Gene
MBP Related reagents
GO Terms
GO:0005886 plasma membrane
GO:0005515 protein binding
GO:0019911 structural constituent of myelin sheath
GO:0043209 myelin sheath
Regulatory
For research purposes only

Applications of MBP

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
ELISA
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using the appropriate negative/positive controls.
Instructions For Use
MBP is a 'sticky' molecule. Glass vials should be used and care should be taken when diluting or transferring this product to avoid loss.

Product Specific References

References for MBP

  1. Addison, G.M. et al. (1984) Fragments of myelin basic protein derived from human brain are not mitogenic in cultures of human amniotic fluid cells and other cells.
    Horm Metab Res. 16 (6): 311-4.
  2. Lutz, D. et al. (2014) Myelin basic protein cleaves cell adhesion molecule l1 and promotes neuritogenesis and cell survival.
    J Biol Chem. 289: 13503-18.
  3. Lutz, D. et al. (2015) Myelin Basic Protein Cleaves Cell Adhesion Molecule L1 and Improves Regeneration After Injury.
    Mol Neurobiol. Jun 17. [Epub ahead of print]