Myelin Basic Protein is one of the most abundant proteins of the myelin membrane in the central nervous system. It plays a role in nerve myelination. MBP may play a role in demyelinating diseases including Multiple Sclerosis.
- Target Species
- Product Form
- Purified protein from bovine brain - lyophilised
- Reconstitute with 1ml of 10mM HCl.
- Buffer Solution
- Essentially salt free
- Preservative Stabilisers
- None Present.
- SDS PAGE: >90%
- Prior to reconstitution store at +4oC.
After reconstitution store at -20oC.
Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the protein. Should this product contain a precipitate we recommend microcentrifugation before use.
- Shelf Life
- 6 months from date of despatch.
- P02687 Related reagents
- Entrez Gene
- MBP Related reagents
- GO Terms
- GO:0005886 plasma membrane
- GO:0005515 protein binding
- GO:0019911 structural constituent of myelin sheath
- GO:0043209 myelin sheath
- For research purposes only
Applications of MBP
|Application Name||Verified||Min Dilution||Max Dilution|
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using the appropriate negative/positive controls.
- Instructions For Use
- MBP is a 'sticky' molecule. Glass vials should be used and care should be taken when diluting or transferring this product to avoid loss.
Copyright © 2018 Bio-Rad Antibodies (formerly AbD Serotec)
Product Specific References
References for MBP
Addison, G.M. et al. (1984) Fragments of myelin basic protein derived from human brain are not mitogenic in cultures of human amniotic fluid cells and other cells.
Horm Metab Res. 16 (6): 311-4.
Lutz, D. et al. (2014) Myelin basic protein cleaves cell adhesion molecule l1 and promotes neuritogenesis and cell survival.
J Biol Chem. 289: 13503-18.
Lutz, D. et al. (2015) Myelin Basic Protein Cleaves Cell Adhesion Molecule L1 and Improves Regeneration After Injury.
Mol Neurobiol. Jun 17. [Epub ahead of print]