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CD209 antibody | MR-1

Mouse anti Human CD209:Low Endotoxin

Product Type
Monoclonal Antibody
Clone
MR-1
Isotype
IgG1
Specificity
CD209

Product Code Applications Pack Size List Price Your Price Qty
MCA2318EL
Datasheet Datasheet Datasheet
SDS Safety Datasheet SDS
F FN IF 0.5 mg loader
List Price Your Price
loader

Mouse anti Human CD209 antibody, clone MR-1 recognizes human DC-specific ICAM-3 grabbing nonintegrin (DC-SIGN), a ~45 kDa C-type lectin that binds ICAM-3 also known as CD209. CD209 is primarily expressed on a population of immature dendritic cells in peripheral tissues and on immature myeloid monocyte-derived DC's in vitro.
CD209 is involved in dendritic cell (DC) migration and the initial interaction between DC's and naive T lymphocytes. CD209 also binds HIV-1 gp120 and plays a key role in the dissemination of HIV-1 by DC's.
Mouse anti Human CD209 antibody, clone MR-1 is reported to partially block the functional activity of DC-SIGN (Melero et al.).

Target Species
Human
Product Form
Purified IgG - liquid
Preparation
Purified IgG prepared by affinity chromatography on Protein A from tissue culture supernatant
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
None present
Carrier Free
Yes
Immunogen
Immature myeloid monocyte-derived dendritic cells (MDDCs).
Approx. Protein Concentrations
IgG concentration 1.0 mg/ml
Endotoxin Level
< 0.01 EU/μg
Fusion Partners
Spleen cells from immunized Balb/c mice were fused with cells of the Mouse SP2/0-Ag14 myeloma cell line.
Regulatory
For research purposes only
Guarantee
12 months from date of despatch

Store at -20°C only.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Flow Cytometry
Functional Assays
Immunofluorescence
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
Flow Cytometry
Use 10μl of the suggested working dilution to label 106 cells in 100μl

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>
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Description Mouse IgG1 Negative Control:Low Endotoxin

References for CD209 antibody

  1. Relloso, M. et al. (2002) DC-SIGN (CD209) expression is IL-4 dependent and is negatively regulated by IFN, TGF-beta, and anti-inflammatory agents.
    J Immunol. 168 (6): 2634-43.
  2. Melero, I. et al. (2002) An anti-ICAM-2 (CD102) monoclonal antibody induces immune-mediated regressions of transplanted ICAM-2-negative colon carcinomas.
    Cancer Res. 62 (11): 3167-74.
  3. Alvarez, C.P. et al (2002) C-type lectins DC-SIGN and L-SIGN mediate cellular entry by Ebola virus in cis and in trans.
    J Virol. 76: 6841-4.
  4. Relloso, M. et al. (2002) Dendritic cell (DC)-specific intercellular adhesion molecule 3 (ICAM-3)-grabbing nonintegrin (DC-SIGN, CD209), a C-type surface lectin in human DCs, is a receptor for Leishmania amastigotes.
    J Biol Chem. 277:36766-9
  5. Chang, S.K. et al. (2008) B lymphocyte stimulator regulates adaptive immune responses by directly promoting dendritic cell maturation.
    J Immunol.180: 7394-403.
  6. Zhang, S.S. et al. (2008) Plasminogen activator Pla of Yersinia pestis utilizes murine DEC-205 (CD205) as a receptor to promote dissemination
    J Biol Chem. 283: 31511-21.
  7. Domínguez-Soto, A. et al. (2011) Dendritic Cell-Specific ICAM-3-Grabbing Nonintegrin Expression on M2-Polarized and Tumor-Associated Macrophages Is Macrophage-CSF Dependent and Enhanced by Tumor-Derived IL-6 and IL-10.
    J Immunol. 186: 2192-200.
  8. Ciudad, M.T. et al. (2017) Analysis of the HLA-DR peptidome from human dendritic cells reveals high affinity repertoires and nonconventional pathways of peptide generation.
    J Leukoc Biol. 101 (1): 15-27.
  9. View The Latest Product References
  10. Chen, J.M. et al. (2017) Bovine Lactoferrin Inhibits Dengue Virus Infectivity by Interacting with Heparan Sulfate, Low-Density Lipoprotein Receptor, and DC-SIGN.
    Int J Mol Sci. 18 (9): 1957.
  11. Pham, H.L. et al. (2023) PDMS Micropatterns Coated with PDA and RGD Induce a Regulatory Macrophage-like Phenotype.
    Micromachines (Basel). 14 (3) :673.
  12. Pham, H.L. et al. (2023) Human Regulatory Macrophages Derived from THP-1 Cells Using Arginylglycylaspartic Acid and Vitamin D3.
    Biomedicines. 11 (6): 1740.

Flow Cytometry

Functional Assays

Synonyms
DC-SIGN
RRID
AB_566636
UniProt
Q9NNX6
Entrez Gene
CD209

MCA2318EL

148129 161572

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