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CD106 antibody | MVCAM A (429)

Product Code Applications Pack Size List Price Your Price Qty
MCA2297GA
Datasheet Datasheet Datasheet
SDS Safety Datasheet SDS
C F IF 0.1 mg loader
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loader
MCA2297
Datasheet Datasheet Datasheet
SDS Safety Datasheet SDS
C F IF 0.25 mg loader
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loader

Rat anti Mouse CD106 antibody, clone MVCAM A (429) recognizes murine vascular adhesion molecule 1 (VCAM-1), a cell surface glycoprotein that is also known as CD106. CD106 is expressed predominantly on endothelial cells and expression is up-regulated during inflammation. The ligand for CD106 is the alpha 4 subunit (CD49d) of the integrin VLA-4 (CD49d/CD29).

Rat anti Mouse CD106 antibody, clone MVCAM A (429) is reported to partially block VCAM-1 mediated functions (Kinashi and Springer 1994).

Target Species
Mouse
Product Form
Purified IgG - liquid
Preparation
Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.09% sodium azide (NaN3)
Carrier Free
Yes
Immunogen
Stromal cell line PA6.
Approx. Protein Concentrations
IgG concentration 1.0 mg/ml
Fusion Partners
Spleen cells from immunized Lewis rats were fused with cells of the mouse P3X63Ag8.653 myeloma cell line.
Regulatory
For research purposes only
Guarantee
12 months from date of despatch

This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.

Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Flow Cytometry 1/10 1/50
Immunofluorescence
Immunohistology - Frozen
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
Flow Cytometry
Use 10μl of the suggested working dilution to label 106 cells in 100μl

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Source Reference

  1. Kinashi, T. and Springer, T.A. (1994) Adhesion molecules in hematopoietic cells.
    Blood Cells. 20:25-44.

References for CD106 antibody

  1. Lau,. H.Y. and Bhatia, M. (2007) Effect of CP-96,345 on the expression of adhesion molecules in acute pancreatitis in mice.
    Am J Physiol Gastrointest Liver Physiol. 292: G1283-92.
  2. Hamada, T. et al. (2008) Metalloproteinase-9 deficiency protects against hepatic ischemia/reperfusion injury.
    Hepatology. 47: 186-98.
  3. Hamada, T. et al. (2009) Inducible nitric oxide synthase deficiency impairs matrix metalloproteinase-9 activity and disrupts leukocyte migration in hepatic ischemia/reperfusion injury.
    Am J Pathol. 174: 2265-77.
  4. Hall, L.J. et al. (2010) Probing local innate immune responses after mucosal immunisation.
    J Immune Based Ther Vaccines. 8: 5.
  5. Woo, J.M. et al. (2010) Treatment with apolipoprotein A-1 mimetic peptide reduces lupus-like manifestations in a murine lupus model of accelerated atherosclerosis.
    Arthritis Res Ther. 12(3):R93.
  6. Chen, Q. et al. (2011) Macrophage binding to receptor VCAM-1 transmits survival signals in breast cancer cells that invade the lungs.
    Cancer Cell. 20 (4): 538-49.
  7. Kuriyama, N. et al. (2011) Tenascin-C: a novel mediator of hepatic ischemia and reperfusion injury.
    Hepatology. 54 (6): 2125-36.
  8. David, S. et al. (2011) Acute administration of recombinant Angiopoietin-1 ameliorates multiple-organ dysfunction syndrome and improves survival in murine sepsis.
    Cytokine. 55 (2): 251-9.
  9. View The Latest Product References
  10. Kümpers, P. et al. (2011) The synthetic tie2 agonist peptide vasculotide protects against vascular leakage and reduces mortality in murine abdominal sepsis.
    Crit Care. 15 (5): R261.
  11. Winnik S et al. (2011) Dietary α-linolenic acid diminishes experimental atherogenesis and restricts T cell-driven inflammation.
    Eur Heart J. 32 (20): 2573-84.
  12. Püntener, U. et al. (2012) Long-term impact of systemic bacterial infection on the cerebral vasculature and microglia.
    J Neuroinflammation. 9: 146.
  13. Li, M. et al. (2014) The indoleamine 2,3-dioxygenase pathway controls complement-dependent enhancement of chemo-radiation therapy against murine glioblastoma.
    J Immunother Cancer. 2: 21.
  14. Braach, N. et al. (2014) RAGE controls activation and anti-inflammatory signalling of protein C.
    PLoS One. 9 (2): e89422.
  15. El Amki, M. et al. (2018) Improved Reperfusion and Vasculoprotection by the Poly(ADP-Ribose)Polymerase Inhibitor PJ34 After Stroke and Thrombolysis in Mice.
    Mol Neurobiol. 55 (12): 9156-68.
  16. Basic, M. et al. (2020) Lymph Node Stromal Cells From Different Draining Areas Distinctly Regulate the Development of Chronic Intestinal Inflammation.
    Front Immunol. 11: 549473.

Immunohistology - Frozen

Synonyms
VCAM-1
RRID
AB_566429
UniProt
P29533
Entrez Gene
Vcam1
GO Terms
GO:0007157 heterophilic cell-cell adhesion
GO:0016021 integral to membrane
GO:0007507 heart development
GO:0031225 anchored to membrane
GO:0044419 interspecies interaction between organisms
GO:0060669 embryonic placenta morphogenesis
GO:0060710 chorio-allantoic fusion

MCA2297GA

151779 163607

MCA2297

0413 151780 167507

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