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CD41 antibody | MWReg30

Product Code Applications Pack Size List Price Your Price Qty
MCA2245GA
Datasheet Datasheet Datasheet
SDS Safety Datasheet SDS
C F IP 0.1 mg loader
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loader
MCA2245T
Datasheet Datasheet Datasheet
SDS Safety Datasheet SDS
C F IP 25 µg loader
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loader
MCA2245
Datasheet Datasheet Datasheet
SDS Safety Datasheet SDS
C F IP 0.25 mg loader
List Price Your Price
loader

Rat anti Mouse CD41 antibody, clone MWReg30 recognizes the mouse integrin alpha IIb subunit CD41. CD41 is a ~125 kDa single pass type 1 transmembrane glycoprotein expressed by platelets, megakaryocytes (Zhang et al. 2007), mast cells (Berlanga et al. 2005), and hematopoietic progenitors (Mitjavila-Garcia et al. 2002). CD41 forms a heterodimer with CD61.

The CD41/CD61 complex is important for platelet adhesion and aggregation (Patel et al. 2003) acting as a receptor for many extracellular matrix proteins including fibronectin, thrombospondin and vitronectin (Weisel et al. 1992).

Rat anti mouse CD41, clone MWReg30 has been reported to inhibit PMA induced aggregation in vitro and to induce hypothermia in vivo (Nieswandt et al. 1999).

Target Species
Mouse
Product Form
Purified IgG - liquid
Preparation
Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.09% sodium azide (NaN3)
Carrier Free
Yes
Immunogen
Purified murine platelets
Approx. Protein Concentrations
IgG concentration 1.0 mg/ml
Regulatory
For research purposes only
Guarantee
12 months from date of despatch

This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.

Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Flow Cytometry 1/50 1/100
Immunohistology - Frozen
Immunoprecipitation
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
Flow Cytometry
Use 10μl of the suggested working dilution to label 106 cells in 100μl

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Description Rabbit F(ab')2 anti Rat IgG:Dylight®800
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Description Rabbit F(ab')2 anti Rat IgG:HRP
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Description Goat F(ab')2 anti Rat IgG:FITC (Mouse Adsorbed)
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Description Goat anti Rat IgG:DyLight®550 (Mouse Adsorbed)
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Description Goat anti Rat IgG:DyLight®650 (Mouse Adsorbed)
Goat anti Rat IgG:Dylight®800 (Mouse Adsorbed) STAR71D800GA F IF WB 0.1 mg loader
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Description Goat anti Rat IgG:Dylight®800 (Mouse Adsorbed)
Goat anti Rat IgG:HRP (Mouse Adsorbed) STAR72 C E P 0.5 mg loader
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Description Goat anti Rat IgG:HRP (Mouse Adsorbed)
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Description Goat F(ab')2 anti Rat IgG:RPE (Mouse Adsorbed)

Source Reference

  1. Nieswandt, B. et al. (1999) Acute systemic reaction and lung alterations induced by an antiplatelet integrin gpIIb/IIIa antibody in mice.
    Blood. 94 (2): 684-93.

References for CD41 antibody

  1. Larson, M.K. and Watson, S.P. (2006) Regulation of proplatelet formation and platelet release by integrin alpha IIb beta3.
    Blood. 108: 1509-14.
  2. Tamagawa-Mineoka, R. et al. (2007) The role of platelets in leukocyte recruitment in chronic contact hypersensitivity induced by repeated elicitation.
    Am J Pathol. 170: 2019-29.
  3. Lutskiy, M.I. et al. (2007) WASP localizes to the membrane skeleton of platelets.
    Br J Haematol. 139: 98-105.
  4. Perez, L.E. et al. (2008) SH2-inositol phosphatase 1 negatively influences early megakaryocyte progenitors.
    PLoS One. 3: e3565.
  5. Zanzinger, K. et al. (2009) Regulation of triggering receptor expressed on myeloid cells 1 expression on mouse inflammatory monocytes.
    Immunology. 128: 185-95.
  6. Winter, O. et al. (2010) Megakaryocytes constitute a functional component of a plasma cell niche in the bone marrow.
    Blood. 116: 1867-75.
  7. Takayama, M. et al. (2010) Genetic analysis of hierarchical regulation for Gata1 and NF-E2 p45 gene expression in megakaryopoiesis.
    Mol Cell Biol. 30: 2668-80.
  8. Sullivan, B.P. et al. (2010) Protective and damaging effects of platelets in acute cholestatic liver injury revealed by depletion and inhibition strategies.
    Toxicol Sci. 115: 286-94.
  9. View The Latest Product References
  10. Motohashi, H. et al. (2010) NF-E2 domination over Nrf2 promotes ROS accumulation and megakaryocytic maturation.
    Blood. 115 (3): 677-86.
  11. Göçmen, A.Y. et al. (2011) Effect of resveratrol on platelet activation in hypercholesterolemic rats: CD40-CD40L system as a potential target.
    Appl Physiol Nutr Metab. 36 (3): 323-30.
  12. Teeling, J.L. et al. (2012) Intracerebral immune complex formation induces inflammation in the brain that depends on Fc receptor interaction
    Acta Neuropathol. 124: 479-90.
  13. Fujita, R. et al. (2013) NF-E2 p45 Is Important for Establishing Normal Function of Platelets.
    Mol Cell Biol. 33: 2659-70.
  14. Goggs, R. et al. (2013) The small GTPase Rif is dispensable for platelet filopodia generation in mice.
    PLoS One. 8 (1): e54663.
  15. Woods, S.J. et al. (2015) Kinetic profiling of in vivo lung cellular inflammatory responses to mechanical ventilation.
    Am J Physiol Lung Cell Mol Physiol. 308 (9): L912-21.
  16. Flierl, U. et al. (2015) Phosphorothioate backbone modifications of nucleotide-based drugs are potent platelet activators.
    J Exp Med. 212 (2): 129-37.
  17. Devanathan, V. et al. (2015) Platelet Gi protein Gαi2 is an essential mediator of thrombo-inflammatory organ damage in mice.
    Proc Natl Acad Sci U S A. 112 (20): 6491-6.
  18. Cuccurullo, A. et al. (2016) Blockade of Thrombopoietin Reduces Organ Damage in Experimental Endotoxemia and Polymicrobial Sepsis.
    PLoS One. 11 (3): e0151088.
  19. Ryan, J. et al. (2016) Myeloid cell-mediated renal injury in rapidly progressive glomerulonephritis depends upon spleen tyrosine kinase.
    J Pathol. 238 (1): 10-20.
  20. Criel, M. et al. (2016) Absence of Pear1 does not affect murine platelet function in vivo.
    Thromb Res. 146: 76-83.
  21. Asai, J. et al. (2016) Platelets Regulate the Migration of Keratinocytes via Podoplanin/CLEC-2 Signaling during Cutaneous Wound Healing in Mice.
    Am J Pathol. 186 (1): 101-8.
  22. Williams, C.M. et al. (2016) Identification of roles for the SNARE-associated protein, SNAP29, in mouse platelets.
    Platelets. 27 (4): 286-94.
  23. Thomson, A.K. et al. (2017) Survival of motor neurone protein is required for normal postnatal development of the spleen.
    J Anat. 230 (2): 337-46.
  24. Moore, S.F. et al. (2021) Opposing Roles of GSK3α and GSK3β Phosphorylation in Platelet Function and Thrombosis.
    Int J Mol Sci. 22(19):10656.

Flow Cytometry

Immunofluorescence

Synonyms
INTEGRIN ALPHA IIB
RRID
AB_323512
UniProt
Q9QUM0
Entrez Gene
Itga2b
GO Terms
GO:0004872 receptor activity
GO:0008305 integrin complex
GO:0005925 focal adhesion
GO:0007160 cell-matrix adhesion
GO:0007229 integrin-mediated signaling pathway
GO:0009897 external side of plasma membrane
GO:0050840 extracellular matrix binding

MCA2245GA

150237 163023

MCA2245T

152411

MCA2245

149127 163142

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