CD79b antibody | AT105-1
Mouse anti Human CD79b:RPE
- Product Type
- Monoclonal Antibody
- Clone
- AT105-1
- Isotype
- IgG1
- Specificity
- CD79b
Mouse anti Human CD79b antibody, clone AT105-1 recognizes an extracellular region of human B-cell antigen receptor complex-associated protein beta chain, also known as CD79b, B-cell-specific glycoprotein B29, Ig-beta or,
Immunoglobulin-associated B29. CD79b is a cell surface antigen expressed by B lymphocytes and associates with CD79a to form a heterodimer, non-covalently linked to surface immunoglobulin, forming the B-cell receptor (BCR) complex. Mutations in the CD79B gene can lead to presentation of Agammaglobulinemia 6, autosomal recessive (AGM6), a disease demonstrating low or absent circulating B cells with the concomitant absence of antibody production. Patients present with multiple severe infections early in life (Dobbs et al. 2007). |
- Target Species
- Human
- Product Form
- Purified IgG conjugated to R. Phycoerythrin (RPE) - lyophilized
- Reconstitution
- Reconstitute with 1.0 ml distilled water
- Preparation
- Purified IgG prepared by affinity chromatography on Protein A from tissue culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% sodium azide (NaN3)
1% bovine serum albumin
5% sucrose - Immunogen
- Peptide corresponding to an extracellular region of CD79 beta
- Fusion Partners
- Spleen cells from immunised mouse were fused with cells of the mouse NS-1 myeloma cell line.
- Max Ex/Em
-
Fluorophore Excitation Max (nm) Emission Max (nm) RPE 488nm laser 496 578 - Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
DO NOT FREEZE.
This product should be stored undiluted. This product is photosensitive and should be protected from light. Should this product contain a precipitate we recommend microcentrifugation before use.
Application Name | Verified | Min Dilution | Max Dilution |
---|---|---|---|
Flow Cytometry | Neat |
- Flow Cytometry
- Use 10μl of the suggested working dilution to label 106 cells in 100μl
How to Use the Spectraviewer
Watch the Tool Tutorial Video ▸- Start by selecting the application you are interested in, with the option to select an instrument from the drop down menu or create a customized instrument
- Select the fluorophores or fluorescent proteins you want to include in your panel to check compatibility
- Select the lasers and filters you wish to include
- Select combined or multi-laser view to visualize the spectra
Description | Product Code | Applications | Pack Size | List Price | Your Price | Quantity | |
---|---|---|---|---|---|---|---|
Mouse IgG1 Negative Control:RPE | MCA928PE | F | 100 Tests | Log in | |||
List Price | Your Price | ||||||
Log in | |||||||
Description | Mouse IgG1 Negative Control:RPE |
Description | Product Code | Applications | Pack Size | List Price | Your Price | Quantity | |
---|---|---|---|---|---|---|---|
Human Seroblock | BUF070A | F | 50 Test | Log in | |||
List Price | Your Price | ||||||
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Description | Human Seroblock | ||||||
Human Seroblock | BUF070B | F | 200 Test | Log in | |||
List Price | Your Price | ||||||
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Description | Human Seroblock |
References for CD79b antibody
-
Cragg, M.S. et al. (2002) The alternative transcript of CD79b is overexpressed in B-CLL and inhibits signaling for apoptosis.
Blood. 100 (9): 3068-76. -
Zheng, B. et al. (2009) In vivo effects of targeting CD79b with antibodies and antibody-drug conjugates.
Mol Cancer Ther. 8 (10): 2937-46.
- Synonyms
- B29
- RRID
- AB_324678
- UniProt
- P40259
- Entrez Gene
- CD79B
- GO Terms
- GO:0004888 transmembrane receptor activity
- GO:0005887 integral to plasma membrane
- GO:0005634 nucleus
- GO:0005794 Golgi apparatus
- GO:0006955 immune response
- GO:0007166 cell surface receptor linked signaling pathway
MCA2208PE
151851If you cannot find the batch/lot you are looking for please contact our technical support team for assistance.
Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"
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