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GluR2 antibody

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Western blot of rat hippocampal lysate showing immunolabeling of the ~100 kDa G1uR2 protein using Rabbit anti Rat GluR2 antibody (AHP986).

Rabbit anti GluR2

Product Type
Polyclonal Antibody
Isotype
Polyclonal IgG
Specificity
GluR2

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Product Code Applications Pack Size List Price Your Price Qty
AHP986
Datasheet Datasheet Datasheet
SDS Safety Datasheet SDS
WB 0.1 ml loader
List Price Your Price
loader

Rabbit anti Human GluR2 antibody recognizes glutamate receptor subunit 2 (GluR2), a component of the AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxalone propionic acid) group of ionotropic glutamate receptors, which play a key role at excitatory synapses, including synaptic transmission, stabilisation and plasticity.

GluR2 is possibly the most important of the AMPA receptor subunits, responsible for AMPA receptor rectifying properties, control of ion flow and in particular the influx of calcium. The majority of GluR2 in the CNS is expressed in the GluR2(R) form, containing a critical arginine residue (as opposed to a glutamine residue) in the Transmembrane region 2 (TM2) domain, thereby rendering native AMPA receptors impermeable to calcium.

Target Species
Rat
Species Cross-Reactivity
Target SpeciesCross Reactivity
Human
Monkey Expected from Sequence
Mouse Expected from Sequence
Chicken Expected from Sequence
Zebrafish Expected from Sequence
N.B. Antibody reactivity and working conditions may vary between species.
Product Form
Purified IgG - liquid
Antiserum Preparation
Antisera to rat GluR2 were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
Buffer Solution
10mM Hepes pH7.5
Preservative Stabilisers
0.09%Sodium Azide
0.01%Bovine Serum Albumin
50%Glycerol
Immunogen
Keyhole limpet haemocyanin conjugated synthetic peptide corresponding to an amino acid sequence within rat GluR2.
Regulatory
For research purposes only
Guarantee
12 months from date of despatch

This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.

Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Western Blotting 1/1000
Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls.
Western Blotting
AHP986 detects a band of approximately 100 kDa in rat brain hippocampus cell lysates.

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Further Reading

  1. Egebjerg, J. et al. (1994) Intron sequence directs RNA editing of the glutamate receptor subunit GluR2 coding sequence.
    Proc Natl Acad Sci U S A. 91 (22): 10270-4.
  2. Vandenberghe, W. et al. (2000) AMPA receptor calcium permeability, GluR2 expression, and selective motoneuron vulnerability.
    J Neurosci. 20 (1): 123-32.

Synonyms
Glutamate Receptor 2
RRID
AB_2113761
UniProt
P19491
Entrez Gene
Gria2
GO Terms
GO:0001919 regulation of receptor recycling
GO:0004971 alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity
GO:0005234 extracellular-glutamate-gated ion channel activity
GO:0005789 endoplasmic reticulum membrane
GO:0007268 synaptic transmission
GO:0008328 ionotropic glutamate receptor complex
GO:0010226 response to lithium ion
GO:0014069 postsynaptic density
GO:0019901 protein kinase binding
GO:0030054 cell junction
GO:0030165 PDZ domain binding
GO:0030426 growth cone
GO:0030672 synaptic vesicle membrane
GO:0031623 receptor internalization
GO:0032279 asymmetric synapse
GO:0032839 dendrite cytoplasm
GO:0042734 presynaptic membrane
GO:0043195 terminal button
GO:0043197 dendritic spine
GO:0043198 dendritic shaft
GO:0043204 perikaryon
GO:0045184 establishment of protein localization
GO:0045211 postsynaptic membrane
GO:0050806 positive regulation of synaptic transmission
GO:0051966 regulation of synaptic transmission, glutamatergic
GO:0060992 response to fungicide

AHP986

147636

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