CD107b antibody
Rabbit anti Human CD107b
- Product Type
- Polyclonal Antibody
- Isotype
- Polyclonal IgG
- Specificity
- CD107b
Antibody Quality and Performance Guarantee
| Rabbit anti Human CD107b antibody recognizes CD107b, also known as LAMP-2, a single-pass type I membrane protein belonging to the LAMP family. CD107b is a transmembrane glycoprotein associated with lysosomal membranes and is primarily expressed on mononuclear phagocytes. Expression of CD107b varies between cell populations and the molecular weight of CD107b can vary between 92-120 kDa. Rabbit anti Human CD107b antibody recognizes a band migrating at ~115 kDa in SDS page. CD107b is involved in a range of cellular processes including leukocyte adhesion (Kannan et al. 1996), protection of the lysosomal membrane from autodigestion, maintenance of the acidic environment of the lysosome along with inter- and intracellular signal transduction (Eskelinen 2006). CD107b has also been implicated in tumor metastasis (Alessandrini et al. 2017). |
- Target Species
- Human
- Species Cross-Reactivity
-
Target Species Cross Reactivity Mouse - N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Purified IgG - liquid
- Antiserum Preparation
- Antiserum to human CD107b was raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.02% Sodium Azide (NaN3)
- Immunogen
- A peptide corresponding to an 17 amino acid sequence from near the carboxyl terminus of human CD107b.
- Approx. Protein Concentrations
- IgG concentration 1.0mg/ml
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Immunohistology - Frozen |  |
10ug/ml | |
| Western Blotting | |
1.0 | 2.0ug/ml |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
- Histology Positive Control Tissue
- HepG2 cells
- Western Blotting
- AHP1634 detects a band of approximately 115kDa in HepG2 cell lysate.
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- Synonyms
- LAMP-2
- RRID
- AB_2280154
- UniProt
- P13473
- Entrez Gene
- LAMP2
- GO Terms
- GO:0005886 plasma membrane
- GO:0002576 platelet degranulation
- GO:0016021 integral to membrane
- GO:0005624 membrane fraction
- GO:0005765 lysosomal membrane
- GO:0005770 late endosome
- GO:0010008 endosome membrane
- GO:0030168 platelet activation
- GO:0031088 platelet dense granule membrane
- View More GO Terms
AHP1634
020315
162848
165816
If you cannot find the batch/lot you are looking for please contact our technical support team for assistance.
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