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Transferrin antibody

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Sheep anti Human Transferrin:FITC

Product Type
Polyclonal Antibody
Isotype
Polyclonal IgG
Specificity
Transferrin

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Sheep anti Human transferrin antibody recognizes human transferrin, an approximately 80 kDa blood plasma glycoprotein synthesised by the liver, which contains two specific high affinity iron (Fe3+) binding sites and is responsible for the transport and supply of an exchangeable pool of iron, through binding to cell surface transferrin receptors.

Transferrin is the primary blood iron transport protein and under normal conditions, approximately one-third of total blood transferrin contains bound iron. Measurement of blood transferrin levels can be used as an indicator for blood iron-carrying capacity and abnormalities of iron metabolism such as anaemia, iron overload and haemochromatosis.

Sheep anti Human transferrin antibody shows minimal cross reactivity with related serum proteins.

Target Species
Human
Product Form
Purified IgG - liquid
Antiserum Preparation
Antisera to human transferrin were raised by repeated immunisations of sheep with highly purified antigen. Purified IgG prepared by affinity chromatography on protein G
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.09%Sodium Azide (NaN3)
Immunogen
Pure human transferrin prepared from pooled normal human serum.
Approx. Protein Concentrations
IgG concentration 1.0mg/ml
Max Ex/Em
Fluorophore Excitation Max (nm) Emission Max (nm)
FITC 490 525
Regulatory
For research purposes only
Guarantee
12 months from date of despatch

This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.

Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended. This product is photosensitive and should be protected from light.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Immunofluorescence
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.

References for Transferrin antibody

  1. Olkhov, R.V. & Shaw, A.M. (2014) Growth kinetics of gold nanoparticles on silica/graphene surfaces for multiplex biological immunoassays
    RSC Adv. 4 (60): 31678-31684.

Further Reading

  1. Giannetti, A.M. et al. (2003) Mechanism for multiple ligand recognition by the human transferrin receptor.
    PLoS Biol. 1 (3): E51.
  2. Rouault, T.A. (2003) How mammals acquire and distribute iron needed for oxygen-based metabolism.
    PLoS Biol. 1 (3): E79.

RRID
AB_808755
UniProt
P02787
Entrez Gene
TF
GO Terms
GO:0002576 platelet degranulation
GO:0005576 extracellular region
GO:0005769 early endosome
GO:0005770 late endosome
GO:0030141 stored secretory granule
GO:0030139 endocytic vesicle
GO:0005905 coated pit
GO:0006879 cellular iron ion homeostasis
GO:0008199 ferric iron binding
GO:0009925 basal plasma membrane
GO:0010008 endosome membrane
GO:0016324 apical plasma membrane
GO:0030168 platelet activation
GO:0033572 transferrin transport
GO:0048471 perinuclear region of cytoplasm
GO:0055037 recycling endosome
GO:0055085 transmembrane transport

9100-0004F

150147

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