Lactate Dehydrogenase 5 antibody
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Sheep anti Human Lactate Dehydrogenase 5
- Product Type
- Polyclonal Antibody
- Isotype
- Polyclonal IgG
- Specificity
- Lactate Dehydrogenase 5
Antibody Quality and Performance Guarantee
| Sheep anti lactate dehydrogenase 5 antibody reacts with LDH2-5, and exhibits low reactivity with LDH1. L-lactate dehydrogenase isozymes exist as tetramers of two subunits with LDH-1 composed for 4 β chains and LDH-5 composed of 4 α chains. LDH-2 =3β:1α, LDH-3 = 2β:2α, LDH-4 = 1β:3α (Boyer et al. 1963). Mutations in the LDHA gene can lead to the development of glycogen storage disease 11 (GSD11), a condition typified by myogloinurea, fatigue and pain. |
- Target Species
- Human
- Product Form
- Purified IgG - liquid
- Preparation
- Purified IgG prepared by affinity chromatography on Protein G
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide (NaN3)
- Immunogen
- Native, highly purified lactate dehydrogenase 5.
- Approx. Protein Concentrations
- IgG concentration 5.0 mg/ml
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| ELISA |  |
||
| Western Blotting | |
1/100 | 1/500 |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using the appropriate negative/positive controls.
| Description | Product Code | Applications | Pack Size | List Price | Your Price | Quantity | |
|---|---|---|---|---|---|---|---|
| Rabbit anti Sheep IgG (H/L):Biotin | 5184-2304 | C E F WB | 1.5 ml |
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| List Price | Your Price | ||||||
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| Description | Rabbit anti Sheep IgG (H/L):Biotin | ||||||
Further Reading
-
Markert, C.L. (1963) Lactate Dehydrogenase Isozymes: Dissociation and Recombination of Subunits.
Science. 140 (3573): 1329-30. -
Augoff, K. et al. (2015) Lactate dehydrogenase 5: an old friend and a new hope in the war on cancer.
Cancer Lett. 358 (1): 1-7. -
Boyer, S.H. et al. (1963) Lactate dehydrogenase variant from human blood: evidence for molecular subunits.
Science. 141 (3581): 642-3.
- RRID
- AB_2137174
- UniProt
- P00338
- Entrez Gene
- LDHA
- GO Terms
- GO:0005515 protein binding
- GO:0004459 L-lactate dehydrogenase activity
- GO:0005829 cytosol
- GO:0006090 pyruvate metabolic process
- GO:0006096 glycolysis
- GO:0055114 oxidation-reduction process
5603-0036
1608
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"
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