Osteocalcin antibody | 3H8H12D2A12F12
Mouse anti Bovine Osteocalcin
- Product Type
- Monoclonal Antibody
- Clone
- 3H8H12D2A12F12
- Isotype
- IgG2a
- Specificity
- Osteocalcin
Mouse anti Bovine Osteocalcin antibody, clone 3H8H12D2A12F12 recognizes intact human and bovine osteocalcin in a "2 site" assay and reacts with osteocalcin fragments corresponding to amino acids 15-31 and 20-43 of the native molecule. It does not recognize fragments representing amino acids 1-19 or 7-19 or intact bovine osteocalcin. Osteocalcin (Bone Gla Protein) is a 49 amino acid single chain vitamin K dependent protein (MW 5.8 kDa), made by osteoblasts that is a major component of the non-collagenous bone matrix. Serum osteocalcin is elevated in diseases characterized by increased bone turnover such as osteoporosis, hyperparathyroidism and Paget’s disease, and low in conditions associated with low bone turnover such as hypoparathyroidism and growth hormone deficiency. |
- Target Species
- Bovine
- Species Cross-Reactivity
-
Target Species Cross Reactivity Rat Rabbit Human Pig - N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Purified IgG - liquid
- Preparation
- Purified IgG prepared by affinity chromatography on Protein A from tissue culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
0.09% Sodium Azide (NaN3) - Carrier Free
- Yes
- Immunogen
- Native bovine osteocalcin.
- Approx. Protein Concentrations
- IgG concentration 1.0 mg/ml
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
Application Name | Verified | Min Dilution | Max Dilution |
---|---|---|---|
ELISA |
- Synonyms
- Bone GLA Protein
- RRID
- AB_2065069
- UniProt
- P02820
- Entrez Gene
- BGLAP
- GO Terms
- GO:0005509 calcium ion binding
- GO:0005576 extracellular region
- GO:0030500 regulation of bone mineralization
- GO:0031214 biomineral tissue development
0400-0042
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"
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