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Hepatitis C E2 Antigen antibody

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Goat anti Hepatitis C E2 Antigen

Product Type
Polyclonal Antibody
Isotype
Polyclonal IgG
Specificity
Hepatitis C E2 Antigen

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Product Code Applications Pack Size List Price Your Price Qty
OBT0993
Datasheet Datasheet Datasheet
SDS Safety Datasheet SDS
E IF WB 1 ml loader
List Price Your Price
loader

Goat anti Hepatitis C E2 antigen antibody recognizes the Hepatitis C virus envelope glycoprotein E2, a 333 amino acid single pass type 1 transmembrane protein also known as NSA, gp68 or gp70. The E2 protein forms a heterodimer with the Envelope glycoprotein E1 and is involved in viral entry into cells. The E2 protein acts as a ligand for CD209 and CLEC4M found on dendritic cells and liver sinusoidal endothelial cells respectively. CLEC4M is also found lymph nide sinusoidal macrophage like cells (UniProt: P26664).

Target Species
Viral
Product Form
Ig Fraction - liquid
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.09% Sodium Azide (NaN3)
Immunogen
Recombinant E2 (genotype 1a).
Approx. Protein Concentrations
1.0 mg/ml
Regulatory
For research purposes only
Guarantee
12 months from date of despatch

This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.

Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
ELISA
Immunofluorescence
Western Blotting
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.

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Further Reading

  1. Scarselli, E. et al. (2002) The human scavenger receptor class B type I is a novel candidate receptor for the hepatitis C virus.
    EMBO J. 21 (19): 5017-25.

Synonyms
HCV
RRID
AB_618825
UniProt
P26664
GO Terms
GO:0004197 cysteine-type endopeptidase activity
GO:0003723 RNA binding
GO:0030529 ribonucleoprotein complex
GO:0004252 serine-type endopeptidase activity
GO:0003968 RNA-directed RNA polymerase activity
GO:0006915 apoptosis
GO:0016021 integral to membrane
GO:0004386 helicase activity
GO:0005198 structural molecule activity
GO:0005524 ATP binding
GO:0005789 endoplasmic reticulum membrane
GO:0006410 transcription, RNA-dependent
GO:0006508 proteolysis
GO:0019079 viral genome replication
GO:0008270 zinc ion binding
GO:0017124 SH3 domain binding
GO:0019028 viral capsid
GO:0019031 viral envelope
GO:0019087 transformation of host cell by virus
GO:0020002 host cell plasma membrane
GO:0030683 evasion by virus of host immune response
GO:0042025 host cell nucleus
GO:0044167 host cell endoplasmic reticulum membrane
GO:0044186 host cell lipid particle
GO:0044191 host cell mitochondrial membrane
GO:0044220 host cell perinuclear region of cytoplasm
GO:0045449 regulation of transcription
GO:0055036 virion membrane

OBT0993

160802

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