Goat anti Hepatitis C E2 antigen antibody
recognizes the Hepatitis C virus envelope glycoprotein E2, a 333 amino acid single pass type 1 transmembrane protein also known as NSA, gp68 or gp70. The E2 protein forms a heterodimer with the Envelope glycoprotein E1 and is involved in viral entry into cells. The E2 protein acts as a ligand for CD209 and CLEC4M found on dendritic cells and liver sinusoidal endothelial cells respectively. CLEC4M is also found lymph nide sinusoidal macrophage like cells (UniProt: P26664
- Target Species
- Product Form
- Ig Fraction - liquid
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide (NaN3)
- Recombinant E2 (genotype 1a).
- Approx. Protein Concentrations
- 1.0 mg/ml
- Store at +4oC or at -20oC if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
- 18 months from date of despatch.
- GO Terms
cysteine-type endopeptidase activity
serine-type endopeptidase activity
RNA-directed RNA polymerase activity
integral to membrane
structural molecule activity
endoplasmic reticulum membrane
viral genome replication
zinc ion binding
SH3 domain binding
transformation of host cell by virus
host cell plasma membrane
evasion by virus of host immune response
host cell nucleus
host cell endoplasmic reticulum membrane
host cell lipid particle
host cell mitochondrial membrane
host cell perinuclear region of cytoplasm
regulation of transcription
- For research purposes only
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Applications of Hepatitis C E2 Antigen antibody
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
Copyright © 2019 Bio-Rad Antibodies (formerly AbD Serotec)
Secondary Antibodies Available
Product Specific References
Scarselli, E. et al. (2002) The human scavenger receptor class B type I is a novel candidate receptor for the hepatitis C virus.
EMBO J. 21 (19): 5017-25.