Rabbit anti Rat TGN38 antibody recognizes a glycoprotein designated TGN38 that is found primarily in the Trans-golgi network, and has been found to be an excellent marker for this cellular organelle.
TGN38 is likely to have a role in intracellular transport. It is the homologue of human TGN46.
- Target Species
- Species Cross-Reactivity
|Target Species||Cross Reactivity|
- N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Serum diluted - liquid
- Antiserum Preparation
- Antisera to TGN38 were raised by repeated immunisations of rabbits with highly purified antigen.
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- <0.1% Sodium Azide (NaN3)
1% Bovine Serum Albumin
- Recombinant protein corresponding to extracellular domain of TGN38.
- This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
- 12 months from date of despatch
- Entrez Gene
- GO Terms
integral to membrane
Golgi to endosome transport
- For research purposes only
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Applications of TGN38 antibody
- 1Fixation with 3% paraformaldehyde or methanol is recommended.
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
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Secondary Antibodies Available
Useful Reagents Available
Product Specific References
References for TGN38 antibody
Ponnambalam, S. et al. (1996) Primate homologues of rat TGN38: primary structure, expression and functional implications.
J Cell Sci. 109 ( Pt 3): 675-85.
Luzio, J.P. et al. (1990) Identification, sequencing and expression of an integral membrane protein of the trans-Golgi network (TGN38).
Biochem J. 270 (1): 97-102.
Banerji, S. et al. (2010) Oxysterol binding protein-dependent activation of sphingomyelin synthesis in the golgi apparatus requires phosphatidylinositol 4-kinase IIα.
Mol Biol Cell. 21 (23): 4141-50.
Park, B.C. et al. (2015) The clathrin-binding and J-domains of GAK support the uncoating and chaperoning of clathrin by Hsc70 in the brain.
J Cell Sci. 128 (20): 3811-21.
Chen, A. et al. (2012) Regional and subcellular distribution of the receptor-targeting protein PIST in the rat central nervous system.
J Comp Neurol. 520 (5): 889-913.
González C et al. (2016) Axons provide the secretory machinery for trafficking of voltage-gated sodium channels in peripheral nerve.
Proc Natl Acad Sci U S A. 113 (7): 1823-8.
Zuidscherwoude, M. et al. (2015) The tetraspanin web revisited by super-resolution microscopy.
Sci Rep. 5: 12201.
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