GluR2 antibody
Rabbit anti GluR2
- Product Type
- Polyclonal Antibody
- Isotype
- Polyclonal IgG
- Specificity
- GluR2
Rabbit anti Human GluR2 antibody recognizes glutamate receptor subunit 2 (GluR2), a component of the AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxalone propionic acid) group of ionotropic glutamate receptors, which play a key role at excitatory synapses, including synaptic transmission, stabilisation and plasticity. GluR2 is possibly the most important of the AMPA receptor subunits, responsible for AMPA receptor rectifying properties, control of ion flow and in particular the influx of calcium. The majority of GluR2 in the CNS is expressed in the GluR2(R) form, containing a critical arginine residue (as opposed to a glutamine residue) in the Transmembrane region 2 (TM2) domain, thereby rendering native AMPA receptors impermeable to calcium. |
- Target Species
- Rat
- Species Cross-Reactivity
-
Target Species Cross Reactivity Human Monkey Expected from Sequence Mouse Expected from Sequence Chicken Expected from Sequence Zebrafish Expected from Sequence - N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Purified IgG - liquid
- Antiserum Preparation
- Antisera to rat GluR2 were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
- Buffer Solution
- 10mM Hepes pH7.5
- Preservative Stabilisers
0.09% Sodium Azide 0.01% Bovine Serum Albumin 50% Glycerol - Immunogen
- Keyhole limpet haemocyanin conjugated synthetic peptide corresponding to an amino acid sequence within rat GluR2.
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
Application Name | Verified | Min Dilution | Max Dilution |
---|---|---|---|
Western Blotting | 1/1000 |
- Western Blotting
- AHP986 detects a band of approximately 100 kDa in rat brain hippocampus cell lysates.
Description | Product Code | Applications | Pack Size | List Price | Your Price | Quantity | |
---|---|---|---|---|---|---|---|
Goat anti Rabbit IgG (Fc):Biotin | STAR121B | E WB | 1 mg | Log in | |||
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Description | Goat anti Rabbit IgG (Fc):Biotin | ||||||
Goat anti Rabbit IgG (Fc):FITC | STAR121F | F | 1 mg | Log in | |||
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Description | Goat anti Rabbit IgG (Fc):FITC | ||||||
Goat anti Rabbit IgG (Fc):HRP | STAR121P | E WB | 1 mg | Log in | |||
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Description | Goat anti Rabbit IgG (Fc):HRP | ||||||
Goat anti Rabbit IgG (H/L):HRP | STAR124P | C E WB | 1 mg | Log in | |||
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Description | Goat anti Rabbit IgG (H/L):HRP | ||||||
Sheep anti Rabbit IgG:RPE | STAR35A | F | 1 ml | Log in | |||
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Description | Sheep anti Rabbit IgG:RPE |
Description | Product Code | Applications | Pack Size | List Price | Your Price | Quantity | |
---|---|---|---|---|---|---|---|
TidyBlot Western Blot Detection Reagent:HRP | STAR209P | WB * | 0.5 ml | Log in | |||
List Price | Your Price | ||||||
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Description | TidyBlot Western Blot Detection Reagent:HRP |
Further Reading
-
Egebjerg, J. et al. (1994) Intron sequence directs RNA editing of the glutamate receptor subunit GluR2 coding sequence.
Proc Natl Acad Sci U S A. 91 (22): 10270-4. -
Vandenberghe, W. et al. (2000) AMPA receptor calcium permeability, GluR2 expression, and selective motoneuron vulnerability.
J Neurosci. 20 (1): 123-32.
- Synonyms
- Glutamate Receptor 2
- RRID
- AB_2113761
- UniProt
- P19491
- Entrez Gene
- Gria2
- GO Terms
- GO:0001919 regulation of receptor recycling
- GO:0004971 alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity
- GO:0005234 extracellular-glutamate-gated ion channel activity
- GO:0005789 endoplasmic reticulum membrane
- GO:0007268 synaptic transmission
- GO:0008328 ionotropic glutamate receptor complex
- GO:0010226 response to lithium ion
- GO:0014069 postsynaptic density
- GO:0019901 protein kinase binding
- View More GO Terms
- GO:0030054 cell junction
- GO:0030165 PDZ domain binding
- GO:0030426 growth cone
- GO:0030672 synaptic vesicle membrane
- GO:0031623 receptor internalization
- GO:0032279 asymmetric synapse
- GO:0032839 dendrite cytoplasm
- GO:0042734 presynaptic membrane
- GO:0043195 terminal button
- GO:0043197 dendritic spine
- GO:0043198 dendritic shaft
- GO:0043204 perikaryon
- GO:0045184 establishment of protein localization
- GO:0045211 postsynaptic membrane
- GO:0050806 positive regulation of synaptic transmission
- GO:0051966 regulation of synaptic transmission, glutamatergic
- GO:0060992 response to fungicide
AHP986
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"
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